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Titolo:
Accumulation of the neutrophil-derived protein YKL-40 during storage of various blood components
Autore:
Cintin, C; Johansen, JS; Skov, F; Price, PA; Nielsen, HJ;
Indirizzi:
Univ Copenhagen, Hvidovre Hosp, Surg Immunol Lab, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 Lab, DK-2650 Hvidovre, Denmark Univ Copenhagen, Hvidovre Hosp, Dept Rheumatol, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 atol, DK-2650 Hvidovre, Denmark Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Biol, La Jolla, CA 92093 USA Univ Copenhagen, Hvidovre Hosp, Dept Surg Gastroenterol 435, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 435, DK-2650 Hvidovre, Denmark
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 2, volume: 50, anno: 2001,
pagine: 107 - 111
SICI:
1023-3830(200102)50:2<107:AOTNPY>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTOPERATIVE INFECTIOUS COMPLICATIONS; INDEPENDENT RISK FACTOR; ACUTE LUNG INJURY; BIOACTIVE SUBSTANCES; COLORECTAL-CANCER; LEUKOCYTE FILTRATION; BACTERIAL-INFECTION; TRANSFUSED BLOOD; MATRIX PROTEIN; SURGERY;
Keywords:
blood transfusion; YKL-40; leuko-depletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Nielsen, HJ Univ Copenhagen, Hvidovre Hosp, Surg Immunol Lab, DK-2650 Hvidovre, Denmark Univ Copenhagen Hvidovre Denmark DK-2650 0 Hvidovre, Denmark
Citazione:
C. Cintin et al., "Accumulation of the neutrophil-derived protein YKL-40 during storage of various blood components", INFLAMM RES, 50(2), 2001, pp. 107-111

Abstract

Objective and Design: Post transfusion infectious complications associatedwith allogeneic blood components may depend on storage time and may be related to extracellular accumulation of bioactive substances during storage. YKL-40 is a glycoprotein located in the specific granules of the neutrophils. While exocytosed it may play a role in inflammation and remodelling of the extracellular matrix. We studied the potential accumulation of YKL-40 inblood components during storage. Methods: Using a RIA method extracellular accumulation of YKL-40 was determined in supernatants from whole blood, plasma-reduced whole blood, buffy-coat-depleted SAGM (saline-adenine-glucose-mannitol) blood, whole blood leukocyte depleted by prestorage filtration, and whole blood leukocyte depletedby bedside filtration. The blood was donated by volunteer, healthy blood donors, and stored under standard blood bank conditions for 35 days. Results: Extracellular accumulation of YKL-40 increased significantly in atime-dependent manner during storage for 35 days of non-filtered whole blood, plasma-reduced whole blood, and SAGM blood, respectively. Prestorage leukocyte depletion of whole blood prevented extracellular YKL-40 accumulation, while YKL-40 accumulation was not reduced by bedside leukocyte depletion. Conclusion: YKL-40 appears to accumulate extracellularly in a time-dependent manner in standard erythrocyte components. Prestorage leukocyte depletion by filtration of whole blood may be an effective procedure to prevent extracellular YKL-40 accumulation during storage of erythrocyte components.

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Documento generato il 09/08/20 alle ore 05:18:52