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Titolo:
Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia
Autore:
Guhring, H; Tegeder, I; Lotsch, J; Pahl, A; Werner, U; Reeh, PW; Rehse, K; Brune, K; Geisslinger, G;
Indirizzi:
Univ Erlangen Nurnberg, Inst Expt Pharmakol & Toxikol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Frankfurt Klinikum, Zentrum Pharmakol, D-60590 Frankfurt, Germany Univ Frankfurt Klinikum Frankfurt Germany D-60590 590 Frankfurt, Germany Univ Erlangen Nurnberg, Inst Physiol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Free Univ Berlin, Inst Pharmaceut Chem, D-14195 Berlin, Germany Free Univ Berlin Berlin Germany D-14195 ut Chem, D-14195 Berlin, Germany
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 2, volume: 50, anno: 2001,
pagine: 83 - 88
SICI:
1023-3830(200102)50:2<83:RONOIZ>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLION; SPINAL-CORD NEURONS; L-NAME; SYNTHASE INHIBITORS; FORMALIN INJECTION; L-ARGININE; KAPPA-B; RAT PAW; CARRAGEENAN; ACTIVATION;
Keywords:
iNOS; thermal hyperalgesia; paw inflammation; spinal cord; NO-donor; zymosan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Geisslinger, G Univ Erlangen Nurnberg, Inst Expt Pharmakol & Toxikol, Fahrstr 17, D-91054Erlangen, Germany Univ Erlangen Nurnberg Fahrstr 17 Erlangen Germany D-91054
Citazione:
H. Guhring et al., "Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia", INFLAMM RES, 50(2), 2001, pp. 83-88

Abstract

Objective: To assess the involvement of spinal inducible nitric oxide synthase (iNOS) in inflammation and nociception. Materials and Methods: The time course of iNOS mRNA expression in rat spinal cord and inflamed paw was assessed by means of quantitative real time RT-PCR. In addition, the effects of the iNOS inhibitor L-NIL on inflammatory paw edema and thermal hyperalgesia were studied in comparison to those of the NO-donor RE-2047. L-NIL (3, 9, 27 and 81 mg/kg) and RE-2047 (3, 9 and 27mg/kg) or vehicle were administered orally 15 min prior to the intraplantar injection of 0.625 mg zymosan. Results: Following zymosan injection, mRNA expression of iNOS increased inthe inflamed paw and spinal cord with a maximum at 2.5 and 4 h, respectively. In the spinal cord iNOS mRNA started to decline at 10h whereas it remained at maximum in the inflamed paw up to the end of the observation period of 24 h. As expected, RE-2047 had significant pronociceptive and proinflammatory effects. L-NIL significantly reduced paw inflammation at 27 and 81 mg/kg but failed to reduce hyperalgesia at the doses tested. Conclusions: The results show that iNOS is upregulated in the inflamed tissue and spinal cord with a similar time course. The effects obtained with L-NIL suggest that iNOS differently contributes to the inflammatory and nociceptive response induced by zymosan.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:04:37