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Titolo:
Protective immunity to UV radiation-induced skin tumours induced by skin grafts and epidermal cells
Autore:
Sluyter, R; Yuen, KS; Halliday, GM;
Indirizzi:
Univ Sydney, Royal Prince Alfred Hosp, Melanoma & Skin Canc Res Inst, DeptMed Dermatol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia2006 rmatol, Sydney, NSW 2006, Australia
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 1, volume: 79, anno: 2001,
pagine: 29 - 34
SICI:
0818-9641(200102)79:1<29:PITURS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC CELLS; LANGERHANS CELLS; ANTITUMOR IMMUNITY; MEDIATED-IMMUNITY; ULTRAVIOLET-LIGHT; TUMORS; ANTIGENS; INDUCTION; MELANOMA; MIGRATION;
Keywords:
antigen-presenting cell; dendritic cell; Langerhans cell; skin graft; UV-induced skin tumour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Halliday, GM Univ Sydney, Dept Dermatol, Blackburn Bldg DO6, Sydney, NSW 2006, Australia Univ Sydney Blackburn Bldg DO6 Sydney NSW Australia 2006 alia
Citazione:
R. Sluyter et al., "Protective immunity to UV radiation-induced skin tumours induced by skin grafts and epidermal cells", IMM CELL B, 79(1), 2001, pp. 29-34

Abstract

There is little evidence that cutaneous dendritic cells (DC), including epidermal Langerhans cells (LC), can induce immunity to UV radiation (UVR)-induced skin tumours. Here, it is shown that cells within skin can induce protective antitumour immunity against a UVR-induced fibrosarcoma. Transplantation of the skin overlying subcutaneous tumours onto naive recipients couldinduce protective antitumour immunity, probably because the grafting stimulated the tumour Ag-loaded DC to migrate to local lymph nodes. This suggests that cutaneous APC can present tumour Ag to induce protective antitumour immunity. Previously, it has been shown that immunization of mice with MHC class II+ epidermal cells (EC) pulsed with tumour extracts could induce delayed-type hypersensitivity against tumour cells. Here, this same immunization protocol could induce protective immunity against a minimum tumorigenic dose of UVR-induced fibrosarcoma cells, but not higher doses. Epidermal cells obtained from semiallogeneic donors and pulsed with tumour extract couldalso induce protective immunity. However, presentation of BSA Ag from the culture medium was found to contribute to this result using semiallogeneic EC. The results suggest that LC overlying skin tumours may be able to induce protective immunity to UVR-induced tumours if stimulated to migrate from the skin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:43:04