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Titolo:
A simultaneous multichannel monophasic action potential electrode array for in vivo epicardial repolarization mapping
Autore:
Sahakian, AV; Peterson, MSL; Shkurovich, S; Hamer, M; Votapka, T; Ji, TY; Swiryn, S;
Indirizzi:
Northwestern Univ, Evanston NW Healthcare, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 ealthcare, Evanston, IL 60208 USA Northwestern Univ, Dept Elect & Comp Engn, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Comp Engn, Evanston, IL 60208 USA Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 omed Engn, Evanston, IL 60208 USA Northwestern Univ, Sch Med, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 , Sch Med, Evanston, IL 60208 USA
Titolo Testata:
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
fascicolo: 3, volume: 48, anno: 2001,
pagine: 345 - 353
SICI:
0018-9294(200103)48:3<345:ASMMAP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORINESS; MODEL;
Keywords:
cardiac mapping; electrodes; epicardium; monophasic action potential; refractory period; repolarization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Sahakian, AV Northwestern Univ, Dept Elect & Comp Engn, Evanston, IL 60208USA Northwestern Univ Evanston IL USA 60208 anston, IL 60208 USA
Citazione:
A.V. Sahakian et al., "A simultaneous multichannel monophasic action potential electrode array for in vivo epicardial repolarization mapping", IEEE BIOMED, 48(3), 2001, pp. 345-353

Abstract

While the recording of extracellular monophasic action potentials (MAPs) from single epicardial or endocardial sites has been performed for over a century, we are unaware of any previous successful attempt to record MAPs simultaneously from a large number of sites in vivo. We report here the designand validation of an array of MAP electrodes which records both depolarization and repolarization simultaneously at up to 16 epicardial sites in a square array on the heart in vivo. The array consists of 16 sintered Ag-AgCl electrodes mounted in a common housing with individual suspensions allowingeach electrode to exert a controlled pressure on the epicardial surface. The electrodes are arranged in a square array, with each quadrant of four having an additional recessed sintered Ag-AgCl reference electrode at its center. A saline-soaked sponge establishes ionic contact between the referenceelectrodes and the tissue. The array was tested on six anesthetized open-chested pigs. Simultaneous diagnostic-quality MAP recordings were obtained from up to 13out of 16 ventricular sites. Ventricular MAPs had amplitudes of 10-40 mV with uniform morphologies and stable baselines for up to 30 min. MAP duration at 90% repolarization was measured and shown to vary as expected with cycle length during sustained pacing. The relationship between MAP duration and effective refractory period was also confirmed, The ability of the array to detect local differences in repolarization was tested in two ways. Placement of the array straddling the atrioventricular (AV) junction yielded simultaneous atrial or ventricular recordings at corresponding sites during 1:1 and 2:1 AV conduction. Localized ischemia via constriction of a coronary artery branch resulted in shortening of the repolarization phase at the ischemic, but not the nonischemic, sites. In conclusion, these results indicate that the simultaneous multichannel MAP electrode array is a viable method for in vivo epicardial repolarizationmapping. The array has the potential to be expanded to increase the numberof sites and spatial resolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:24:23