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Titolo:
Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI
Autore:
Kimberg, DY; Aguirre, GK; Lease, J; DEsposito, M;
Indirizzi:
Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Neurol, Philadelphia, PA 19104 USA
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 4, volume: 12, anno: 2001,
pagine: 246 - 257
SICI:
1065-9471(200104)12:4<246:CEOBAD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; DELAYED-RESPONSE TASK; CARD SORTING TEST; WORKING-MEMORY; PREFRONTAL CORTEX; EMPIRICAL ANALYSES; NULL-HYPOTHESIS; PERFORMANCE; MODULATION; MONKEYS;
Keywords:
working memory; cognition; fMRI; dopamine; neuroimaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kimberg, DY Hosp Univ Penn, Dept Neurol, 3W Gates,Area 9,3400 Spruce St, Philadelphia,PA 19104 USA Hosp Univ Penn 3W Gates,Area 9,3400 Spruce St Philadelphia PA USA 19104
Citazione:
D.Y. Kimberg et al., "Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI", HUM BRAIN M, 12(4), 2001, pp. 246-257

Abstract

Studies of human subjects performing cognitive tasks on and off dopaminergic drugs have suggested a specific role of dopamine in cognitive processes,particularly in working memory and prefrontal "executive" functions. However, the cortical effects of these drugs have been poorly understood. We used functional magnetic resonance imaging (fMRI) to examine both task-specific and general changes in cortical activity associated with bromocriptine, aselective agonist for D-2 dopamine receptors. Bromocriptine resulted in task-specific modulations of task-related activity in three cognitive tasks. Across tasks, the overall effect of the drug was to reduce task-related activity. We also observed drug effects on behavior that correlated with individual differences in memory span. We argue that bromocriptine may show bothtask-specifc modulation and task-general inhibition of neural activity dueto dopaminergic neurotransmission. Hum. Brain Mapping 22:246-257, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:52:56