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Titolo:
Precursor lesions of ovarian epithelial malignancy
Autore:
Feeley, KM; Wells, M;
Indirizzi:
Univ Sheffield, Sch Med, Dept Pathol, Sheffield S10 2RX, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2RX S Yorkshire, England Royal Hallamshire Hosp, Dept Histopathol, Sheffield S10 2JF, S Yorkshire, England Royal Hallamshire Hosp Sheffield S Yorkshire England S10 2JF ire, England
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 2, volume: 38, anno: 2001,
pagine: 87 - 95
SICI:
0309-0167(200102)38:2<87:PLOOEM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE-I CARCINOMAS; ENDOMETRIOTIC CYSTS; SURFACE EPITHELIUM; MICROSATELLITE INSTABILITY; BORDERLINE MALIGNANCY; EXTRACELLULAR-MATRIX; PROTEIN ACCUMULATION; CONTRALATERAL OVARY; POTENTIAL TUMORS; FAMILY HISTORY;
Keywords:
ovary; ovarian cancer precursors; borderline tumours; endometriosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Wells, M Univ Sheffield, Sch Med, Dept Pathol, Sheffield S10 2RX, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2RX re, England
Citazione:
K.M. Feeley e M. Wells, "Precursor lesions of ovarian epithelial malignancy", HISTOPATHOL, 38(2), 2001, pp. 87-95

Abstract

Most ovarian carcinomas arise from the mesothelial surface lining of the ovaries, or from invaginations of this lining into the superficial ovarian cortex to form cortical inclusion cysts. The native ovarian surface mesothelium is of an 'uncommitted' phenotype, and has potential to modulate to epithelial or mesenchymal phenotypes in response to signals such as those associated with ovulation. The exposure of the mesothelial lining of an inclusion cyst to the ovarian stromal microenvironment may be responsible for the phenotypic change to Mullerian epithelium so commonly seen in these cysts. Mullerian metaplasia is usually to a serous phenotype, and it is possible that undefined molecular events occurring in an inclusion cyst that has undergone Mullerian metaplasia may initiate neoplastic change in these cysts. This may be the developmental pathway of most invasive serous carcinomas. Occasional rare cases of ovarian intraepithelial neoplasia, manifested by epithelial atypia in an inclusion cyst or on the surface epithelium without invasive carcinoma, are identified histologically. Serous borderline tumours represent a separate category and in most cases probably do not progress to frank carcinoma. Mucinous carcinomas may in some cases have arisen from pre-existing benign and borderline mucinous tumours. Endometriosis of the ovary is associated with genetic abnormalities and is frequently found in association with clear cell and endometrioid carcinomas, suggesting that in manycases these latter two types of carcinoma may have arisen directly from endometriotic deposits, Ovaries removed prophylactically from women with a family history of ovarian carcinoma or with a mutation in one of the genes predisposing to ovarian carcinoma should be processed in their entirety, and examined closely not just for obviously neoplastic lesions, but also for more subtle morphological abnormalities of the surface epithelium or the epithelium lining cortical inclusion cysts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:27:08