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Titolo:
Long-term effects of vitamin B-12, folate, and vitamin B-6 supplements in elderly people with normal serum vitamin B-12 concentrations
Autore:
Henning, BF; Tepel, M; Riezler, R; Naurath, HJ;
Indirizzi:
Ruhr Univ Bochum, Med Klin 1, Marien Hosp, Dept Internal Med 1, D-44625 Herne, Germany Ruhr Univ Bochum Herne Germany D-44625 nal Med 1, D-44625 Herne, Germany Severi Med GmbH, Munster, Germany Severi Med GmbH Munster GermanySeveri Med GmbH, Munster, Germany FEK Neumunster, Dept Geriatr Med, Neumunster, Germany FEK Neumunster Neumunster Germany Dept Geriatr Med, Neumunster, Germany
Titolo Testata:
GERONTOLOGY
fascicolo: 1, volume: 47, anno: 2001,
pagine: 30 - 35
SICI:
0304-324X(200101/02)47:1<30:LEOVBF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; CHROMATOGRAPHY MASS-SPECTROMETRY; TOTAL HOMOCYSTEINE; COBALAMIN DEFICIENCY; PLASMA HOMOCYSTEINE; METHYLMALONIC ACID; ELEVATION; DISORDERS; RISK; URINE;
Keywords:
homocysteine metabolism; vitamin B-12; folate; vitamin B-6; elderly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Henning, BF Ruhr Univ Bochum, Med Klin 1, Marien Hosp, Dept Internal Med 1, Holkeskampring 40, D-44625 Herne, Germany Ruhr Univ Bochum Holkeskampring40 Herne Germany D-44625 many
Citazione:
B.F. Henning et al., "Long-term effects of vitamin B-12, folate, and vitamin B-6 supplements in elderly people with normal serum vitamin B-12 concentrations", GERONTOLOGY, 47(1), 2001, pp. 30-35

Abstract

Background: In the elderly, deficiencies of folate, cobalamin (vitamin B-12) and pyridoxal phosphate (vitamin Bg) are common. The metabolites homocysteine, methylmalonic acid, 2-methylcitric acid and cystathionine have been reported to be sensitive markers of these vitamin deficiencies. Objective: The long-term (269 days) effect of an intramuscular vitamin supplement containing 1 mg vitamin B-12, 1 1 mg folate, and 5 mg vitamin B-6 On serum concentrations of homocysteine (tHcy), methylmalonic acid (MMA), 2-methylcitricacid (2-MCA), and cystathionine (Cysta) was studied in 49 elderly subjectswith normal levels of vitamin B-12. Methods: Vitamin supplement was administered 8 times over a 21-day period, metabolite concentrations were measured until day 269 (e.g. 248 days after the end of vitamin supplementation). Results: From day 0 to 21, the serum levels of the 3 vitamins increased significantly, after cessation of supplementation the levels returned to baseline within the follow-up period. The MMA, 2-MCA and tHcy levels decreased during the treatment period significantly and did not reach baseline values within the 248-day period. Cysta levels did not differ significantly from baseline, either during or after treatment. Conclusion: MMA and 2-MCA levels rather reflect the availability of vitamins, especially cobalamin, than theactual serum levels. Since deficiencies of folate, cobalamin and pyridoxalphosphate in the elderly may cause hyerhomocysteinemia and hence may have unfavorable effects on mental performance, determination of MMA and 2-MCA levels in elderly patients with mental disturbances may be a cost-effective measure to improve or maintain mental performance. Copyright (C) 2001 S. Karger AG,Basel.

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Documento generato il 09/07/20 alle ore 20:56:42