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Titolo:
Pharmacologically regulated gene expression in the retina following transduction with viral vectors
Autore:
Dejneka, NS; Auricchio, A; Maguire, AM; Ye, X; Gao, GP; Wilson, JM; Bennett, J;
Indirizzi:
Univ Penn, Scheie Eye Inst, Stellar Chance Labs 310, Inst Human Gene Therapy,Dept Ophthalmol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 phthalmol, Philadelphia, PA 19104 USA Univ Penn, Dept Mol & Cellular Engn, Inst Human Gene Therapy, Wistar Inst,Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 istar Inst,Philadelphia, PA 19104 USA Childrens Natl Med Ctr, Childrens Res Inst, Med Genet Res Ctr, Washington,DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 r, Washington,DC 20010 USA
Titolo Testata:
GENE THERAPY
fascicolo: 6, volume: 8, anno: 2001,
pagine: 442 - 446
SICI:
0969-7128(200103)8:6<442:PRGEIT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT ADENOASSOCIATED VIRUS; IN-VIVO; MAMMALIAN-CELLS; RHODOPSIN GENE; MICE; THERAPY; MOUSE; PIGMENTOSA; TOXICITY; MUTATION;
Keywords:
adenovirus; tetracycline-inducible gene expression system; enhanced green fluorescent protein; human growth hormone; retinal pigment epithelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bennett, J Univ Penn, Scheie Eye Inst, Stellar Chance Labs 310, Inst HumanGene Therapy,Dept Ophthalmol, 422 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 422 Curie Blvd Philadelphia PA USA 19104 PA 19104 USA
Citazione:
N.S. Dejneka et al., "Pharmacologically regulated gene expression in the retina following transduction with viral vectors", GENE THER, 8(6), 2001, pp. 442-446

Abstract

The availability of inducible expression systems makes regulatable controlof therapeutic proteins an attainable goal in gene therapy. We delivered tetracycline-inducible transgenes to the subretinal space using recombinant adenoviruses. Upon administration of doxycycline, we demonstrated reversible expression of green fluorescent protein in the retinal pigment epitheliumas well as modulation of human growth hormone produced in the retina and secreted in the blood stream. This mode of delivery and regulation offers a unique way to evaluate gene function in the eye and represents a novel method for introducing therapeutic proteins into the retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:23:00