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Titolo:
A new cause of Zollinger-Ellison syndrome: Non-small cell lung cancer
Autore:
Abou-Saif, A; Lei, JY; McDonald, TJ; Chakrabarti, S; Waxman, IF; Shojamanesh, H; Schrump, DS; Kleiner, DE; Gibril, F; Jensen, RT;
Indirizzi:
NIDDK, Digest Dis Branch, NIH, Bethesda, MD 20892 USA NIDDK Bethesda MD USA 20892 igest Dis Branch, NIH, Bethesda, MD 20892 USA NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA NCI, Thorac Oncol Sect, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Thorac Oncol Sect, NIH, Bethesda, MD 20892 USA Univ Western Ontario, Dept Pathol, London, ON, Canada Univ Western Ontario London ON Canada o, Dept Pathol, London, ON, Canada Univ Western Ontario, Dept Med, London, ON, Canada Univ Western Ontario London ON Canada ario, Dept Med, London, ON, Canada Univ Texas, Med Branch, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 as, Med Branch, Galveston, TX 77550 USA
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 5, volume: 120, anno: 2001,
pagine: 1271 - 1278
SICI:
0016-5085(200104)120:5<1271:ANCOZS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIN-RELEASING PEPTIDE; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; ECTOPIC HORMONE PRODUCTION; ULTRASTRUCTURAL ANALYSIS; USEFUL MARKER; LONG-TERM; CARCINOMA; ULCER; DEATH; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Jensen, RT NIDDK, Digest Dis Branch, NIH, Bldg 10,Room 9C-103,10 Ctr Dr,MSC 1804, Bethesda, MD 20892 USA NIDDK Bldg 10,Room 9C-103,10 Ctr Dr,MSC 1804Bethesda MD USA 20892
Citazione:
A. Abou-Saif et al., "A new cause of Zollinger-Ellison syndrome: Non-small cell lung cancer", GASTROENTY, 120(5), 2001, pp. 1271-1278

Abstract

Numerous epidemiologic studies suggest a relationship between lung cancer and peptic ulcer disease. Furthermore, various lung cancers synthesize and release a number of peptides such as gastrin and gastrin-releasing peptide that could cause acid hypersecretion; however, Zollinger-Ellison syndrome (ZES), because of a lung tumor, has never been described. We report such a patient for the first time. A 60-year-old man with a non-small cell lung carcinoma (large cell type) presented with diarrhea, heartburn, abdominal pain, and duodenal ulcers, Evaluation showed ZES was present (fasting hypergastrinemia, hyperchlorhydria) and control of all symptoms by omeprazole. No abdominal or cardiac tumor, the other known locations of gastrinomas causing ZES, was found on detailed tumor imaging studies. Resection of the lung tumor resulted in a decrease in gastrin levels to normal values, Plasma radioimmunoassays showed elevated gastrin, chromogranin A and normal levels of gastrin-releasing peptide, and 9 other hormones. The tumor showed similar immunocytochemical results. The characteristics of this case are compared with100 cases of sporadic abdominal gastrinomas, and the evidence reviewed suggests why ZES should be considered in patients with lung cancer with pepticsymptoms.

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Documento generato il 14/07/20 alle ore 17:51:42