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Titolo:
Physiological oxidative stress model: Syrian hamster Harderian gland - Sexdifferences in antioxidant enzymes
Autore:
Coto-Montes, A; Boga, JA; Tomas-Zapico, C; Rodriguez-Colunga, MJ; Martinez-Fraga, J; Tolivia-Cadrecha, D; Menedez, G; Hardeland, R; Tolivia, D;
Indirizzi:
Univ Oviedo, Dept Morphol & Cellular Biol, E-33006 Oviedo, Spain Univ Oviedo Oviedo Spain E-33006 & Cellular Biol, E-33006 Oviedo, Spain Univ Oviedo, Dept Biochem & Mol Biol, E-33006 Oviedo, Spain Univ Oviedo Oviedo Spain E-33006 ochem & Mol Biol, E-33006 Oviedo, Spain Inst Zool & Anthropol, Gottingen, Germany Inst Zool & Anthropol Gottingen Germany & Anthropol, Gottingen, Germany
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 7, volume: 30, anno: 2001,
pagine: 785 - 792
SICI:
0891-5849(20010401)30:7<785:POSMSH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALE GOLDEN-HAMSTER; DROSOPHILA-MELANOGASTER; GLUTATHIONE-PEROXIDASE; GENE-EXPRESSION; CELL-DAMAGE; MELATONIN; PORPHYRINS; CASTRATION; HORMONES; ASSAYS;
Keywords:
catalase; superoxide dismutase; glutathione peroxidase; glutathione reductase; circadian rhythm; Harderian gland; hamster; antioxidant enzyme; free radicals; porphyria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Coto-Montes, A Univ Oviedo, Dept Morphol & Cellular Biol, Julian Claveria S-N, E-33006 Oviedo, Spain Univ Oviedo Julian Claveria S-N Oviedo Spain E-33006 Spain
Citazione:
A. Coto-Montes et al., "Physiological oxidative stress model: Syrian hamster Harderian gland - Sexdifferences in antioxidant enzymes", FREE RAD B, 30(7), 2001, pp. 785-792

Abstract

The Syrian hamster Harderian gland, a juxtaorbital organ exhibiting markedgender-associated differences in contents of porphyrins and melatonin, wasused as a model system for comparing strong tin females) and moderate tin males) physiologoical oxidative stress. Histological differences showing much higher cell damage in females were studied in conjunction with lipid peroxidation and activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. Lipid peroxidation and enzyme activities were measured throughout the circadian cycle, revealing the importance ofdynamical processes in oxidative stress. Especially in lipid peroxidation and in catalase, short-lasting rises exhibited strongest gender differences. Peaks of lipid peroxidation were about three times higher in females, compared to males. Catalase peaks of females exceeded those in males by several hundred-fold. Average levels of superoxide dismutase and glutathione peroxidase were about three or two times higher in females, respectively. A clear-cut diurnally peaking rhythm was found in glutathione peroxidase of females, which was not apparent in males. Glutathione reductase showed differences in time patterns, but less in average activities. The time courses of lipid peroxidation and of protective enzymes are not explained by circulating melatonin, whereas melatonin formed in the Harderian gland should contribute to differences in average levels. Neither damage nor antioxidative defense simply reflect the illumination cycle and are, therefore, not only a consequence of photoreactions. (C) 2001 Elsevier Science Inc.

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Documento generato il 04/04/20 alle ore 11:53:11