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Titolo:
Immunohistochemical investigation of pulmonary surfactant-associated protein A in fatal poisoning
Autore:
Zhu, BL; Ishida, K; Oritani, S; Quan, L; Fujita, MQ; Maeda, H; Ogawa, M; Tanaka, N; Komura, S; Tsuji, T;
Indirizzi:
Osaka City Univ, Sch Med, Dept Legal Med, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Med, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Hosp Pharm, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 harm, Abeno Ku, Osaka 5458585, Japan Univ Occupat & Environm Hlth, Sch Med, Dept Forens Med, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Kyoto Prefectural Univ Med, Dept Legal Med, Kamigyo Ku, Kyoto 6020841, Japan Kyoto Prefectural Univ Med Kyoto Japan 6020841 Ku, Kyoto 6020841, Japan Wakayama Med Coll, Dept Legal Med, Wakayama 6410012, Japan Wakayama Med Coll Wakayama Japan 6410012 al Med, Wakayama 6410012, Japan
Titolo Testata:
FORENSIC SCIENCE INTERNATIONAL
fascicolo: 3, volume: 117, anno: 2001,
pagine: 205 - 212
SICI:
0379-0738(20010401)117:3<205:IIOPSP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG SURFACTANT; ALVEOLAR WALLS; HYPOXIC STATE; APOPROTEIN-A; ASPHYXIA; DEATH; RATS; PHOSPHOLIPIDS;
Keywords:
forensic pathology; immunohistochemistry; pulmonary surfactant-associated protein A; respiratory distress; poisoning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Zhu, BL Osaka City Univ, Sch Med, Dept Legal Med, Abeno Ku, Asahi Machi 1-4-3, Osaka 5458585, Japan Osaka City Univ Asahi Machi 1-4-3 Osaka Japan 5458585 8585, Japan
Citazione:
B.L. Zhu et al., "Immunohistochemical investigation of pulmonary surfactant-associated protein A in fatal poisoning", FOREN SCI I, 117(3), 2001, pp. 205-212

Abstract

To evaluate the immunohistochemical distribution of pulmonary surfactant-associated protein A (SP-A) in fatal poisoning in relation to the effects ofdrugs and poisons on respiratory function, 42 forensic autopsy cases were examined by scoring the staining intensity. The highest scores: of SP-A staining, with dense granular deposits (aggregates) in the intra-alveolar space, were observed in fatalities from pancuronium bromide (muscle relaxant) injection and petroleum (butane) gas inhalation. Poisoning with organophosphate pesticides and arsenic (ingestion) showed a second grade SP-A score. However, The SP-A scores were relatively low in ethanol and sedative-hypnoticintoxication. Carbon monoxide intoxication showed a varied degree of SP-A score, and the aggregated SP-A score tended to be higher in cases of lower blood carboxyhemoglobin concentration. A varied SP-A score was also observed in methamphetamine fatalities, in which the score was relatively low in cases with a higher serum drug level. Increase of SP-A was not always associated with the intra-alveolar effusion or hemorrhages. The above-described observations suggested that the immunohistochemical score of SP-A may be a possible indication for intensity and duration of drug/poison-dependent respiratory distress. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 01/12/20 alle ore 00:47:42