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Titolo:
Urinary thiocyanate levels as a biomarker for the generation of inorganic cyanide from benzyl cyanide in the rat
Autore:
Potter, J; Smith, RL; Api, AM;
Indirizzi:
Res Inst Fragrance Mat Inc, Hackensack, NJ 07601 USA Res Inst Fragrance Mat Inc Hackensack NJ USA 07601 ckensack, NJ 07601 USA Quintiles England Ltd, Quintiles Toxicol Pathol Serv, Ledbury HR8 1LH, England Quintiles England Ltd Ledbury England HR8 1LH , Ledbury HR8 1LH, England Imperial Coll, Sch Med, Div Biomed Sci, Sect Mol Toxicol, London SW7 2AZ, England Imperial Coll London England SW7 2AZ ol Toxicol, London SW7 2AZ, England
Titolo Testata:
FOOD AND CHEMICAL TOXICOLOGY
fascicolo: 2, volume: 39, anno: 2001,
pagine: 141 - 146
SICI:
0278-6915(200102)39:2<141:UTLAAB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALIPHATIC NITRILES; TOXICITY;
Keywords:
rat urine analysis; cyanide; thiocyanate; method;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Api, AM Res Inst Fragrance Mat Inc, 2 Univ Plaza,Suite 406, Hackensack, NJ07601 USA Res Inst Fragrance Mat Inc 2 Univ Plaza,Suite 406 Hackensack NJ USA 07601
Citazione:
J. Potter et al., "Urinary thiocyanate levels as a biomarker for the generation of inorganic cyanide from benzyl cyanide in the rat", FOOD CHEM T, 39(2), 2001, pp. 141-146

Abstract

A colorimetric procedure was developed and validated for the determinationof thiocyanate in rat urine over the concentration range of 7-7000 mug/ml. It was applied to the determination of thiocyanate following its oral administration to male and female rats. The mean percentage urinary recoveries of sodium thiocyanate given by oral gavage at 10 and 100 mg/kg were 60 and 39%, respectively, for male rats and 89 and 73% for females over a period of 3 days. Most of the elimination occurred in the 0-48-h period post-dosingbut significant amounts were still being excreted in the 48-72-h period. It was concluded from these results that the recoveries of urinary thiocyanate were such that this anion was suitable for use as a biomarker for the release of cyanide from organonitriles such as benzyl cyanide. Benzyl cyanide(150 mg/kg) administered orally to rats led to markedly increased urinary thiocyanate levels; for male rats this was equivalent to 54% of the dose and for females this was 65% over a period of 3 days. When adjusted for incomplete recoveries of the marker, thiocyanate, these values equated to 61 and89%, respectively. It was concluded that this validated assay could be used to assess cyanide release from topically applied fragrance organonitriles(Potter, J., Smith, R.L., Api, A.M., 2000. An assessment of the release ofinorganic cyanide from the fragrance materials, benzyl cyanide, geranyl nitrile and citronellyl nitrile applied dermally to the rat. Food and Chemical Toxicology 39 147-151). (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:34:41