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Titolo:
On the presence of peptide synthetase and polyketide synthase genes in thecyanobacterial genus Nodularia
Autore:
Moffitt, MC; Neilan, BA;
Indirizzi:
Univ New S Wales, Sch Microbiol & Immunol, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 l, Sydney, NSW 2052, Australia
Titolo Testata:
FEMS MICROBIOLOGY LETTERS
fascicolo: 2, volume: 196, anno: 2001,
pagine: 207 - 214
SICI:
0378-1097(20010315)196:2<207:OTPOPS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-2A PROTEIN PHOSPHATASES; HEPATOTOXIN PRODUCTION; SPUMIGENA MERTENS; POTENT INHIBITOR; BIOSYNTHESIS; MICROCYSTIS; TOXICITY; STRAINS; BLOOM; TOXIN;
Keywords:
nodularin; peptide synthetase; polyketide synthase; cyanobacterium; Nodularia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Neilan, BA Univ New S Wales, Sch Microbiol & Immunol, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 NSW 2052, Australia
Citazione:
M.C. Moffitt e B.A. Neilan, "On the presence of peptide synthetase and polyketide synthase genes in thecyanobacterial genus Nodularia", FEMS MICROB, 196(2), 2001, pp. 207-214

Abstract

Nodularin is a hepatotoxin produced by the bloom-forming cyanobacterial species Nodularia spumigena. Putative peptide synthetase and polyketide synthase genes were detected in toxic strains of Nodularia by degenerate PCR. Using specific primer sets, peptide synthetase and polykelide synthase gene homologues were detected in nodularin-producing strains indicating a possible role of peptide synthetase and polyketide synthase enzyme complexes in the biosynthesis of nodularin. Strains of Nodularia isolated from around the world were also analyzed for the production of nodularin by the protein phosphatase 2A inhibition assay. The protein phosphatase inhibition assay and the molecular detection of peptide synthetase and polykelide synthase genesin Nodularia may be useful techniques for the assessment of nodularin-producing cyanobacteria in the environment. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:34:36