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Titolo:
Analysis of host responses of guinea pigs during Helicobacter pylori infection
Autore:
Rijpkema, SG; Durrani, Z; Beavan, G; Gibson, JR; Luck, J; Owen, RJ; Auda, GR;
Indirizzi:
Natl Inst Biol Stand & Controls, Div Bacteriol, Potters Bar EN6 3QG, Herts, England Natl Inst Biol Stand & Controls Potters Bar Herts England EN6 3QG England Natl Inst Biol Stand & Controls, Div Virol, Potters Bar EN6 3QG, Herts, England Natl Inst Biol Stand & Controls Potters Bar Herts England EN6 3QG England Publ Hlth Lab Serv, Cent Publ Hlth Lab, Helicobacter Reference Unit, London NW9 5EQ, England Publ Hlth Lab Serv London England NW9 5EQ Unit, London NW9 5EQ, England
Titolo Testata:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
fascicolo: 2, volume: 30, anno: 2001,
pagine: 151 - 156
SICI:
0928-8244(200103)30:2<151:AOHROG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIN PRODUCTION; NONHUMAN-PRIMATES; HUMAN-DISEASE; GASTRITIS; DIVERSITY; HISTOLOGY; MODEL; VACA;
Keywords:
Helicobacter pylori; infection model; guinea pig; immunoglobulin G2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Rijpkema, SG Natl Inst Biol Stand & Controls, Div Bacteriol, Blanche Lane,Potters Bar EN6 3QG, Herts, England Natl Inst Biol Stand & Controls Blanche Lane Potters Bar Herts England EN6 3QG
Citazione:
S.G. Rijpkema et al., "Analysis of host responses of guinea pigs during Helicobacter pylori infection", FEMS IM MED, 30(2), 2001, pp. 151-156

Abstract

Host responses of guinea pigs infected with Helicobacter pylori were investigated. Passaged pylori colonised the stomach for up to 13 weeks after infection, but after 1 month the number of bacteria fell sharply. Specific antibodies, predominantly of the IgG2 subtype, were present from week 3 onwards. Antibodies to urease A and flagella were abundant. Severe inflammation of the gastric mucosa and damage to the stomach epithelium was seen. Infiltrates of mononuclear cells and eosinophils were found near the parietal glands. As infection progressed, inflammation and tissue damage became more localised and more variable between individual animals. These parameters can be used as markers for colonisation of the stomach by H. pylori. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 21:07:02