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Titolo:
Genetic linkage of nuclear morphology of mouse lung tumors to the Kras-2 locus
Autore:
Tripodis, N; Demant, P;
Indirizzi:
Netherlands Canc Inst, Div Mol Genet H5, NL-1066 CX Amsterdam, NetherlandsNetherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands
Titolo Testata:
EXPERIMENTAL LUNG RESEARCH
fascicolo: 3, volume: 27, anno: 2001,
pagine: 185 - 196
SICI:
0190-2148(200104/05)27:3<185:GLONMO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT CONGENIC STRAINS; INDUCED PULMONARY ADENOMAS; RESISTANCE LOCUS; SUSCEPTIBILITY; MICE; CANCER; CELL; ORIGIN; TRAITS; A/J;
Keywords:
Kras-2; linkage analysis; lung tumors; lymphocytic infiltration; mouse; nuclear cytoplasmic invaginations; qualitative analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Demant, P Netherlands Canc Inst, Div Mol Genet H5, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Plesmanlaan 121 Amsterdam Netherlands NL-1066 CX
Citazione:
N. Tripodis e P. Demant, "Genetic linkage of nuclear morphology of mouse lung tumors to the Kras-2 locus", EXP LUNG R, 27(3), 2001, pp. 185-196

Abstract

Search for quantitative trait loci (QZLs) has been successful in the past decade by revealing numerous susceptibility to lung cancer loci in specially designed experimental crosses in mice. Although qualitative aspects of lung tumorigenesis are also genetically controlled, no loci affecting such traits have so far been identified. We analyzed a series of lung rumors derived from various inbred and recombinant congenic strains and F2 crosses for two histological characteristics: nuclear cytoplasmic invaginations (NCIs) and lymphocytic infiltration (LI) and performed linkage analysis. A significant linkage of the Kras-2 locus with presence or absence of NCI was detected. The implications of this linkage as well as the relationships between NCI, LI, tumor size and Kras-2 alleles are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:29:45