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Titolo:
Structural analysis reflects the evolutionary relationship between the human desmocollin gene family members
Autore:
Cserhalmi-Friedman, PB; Frank, JA; Ahmad, W; Panteleyev, AA; Aita, VM; Christiano, AM;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Dermatol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ NewYork NY USA 10032 t Genet & Dev, New York, NY 10032 USA
Titolo Testata:
EXPERIMENTAL DERMATOLOGY
fascicolo: 2, volume: 10, anno: 2001,
pagine: 95 - 99
SICI:
0906-6705(200104)10:2<95:SARTER>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEMPHIGUS-VULGARIS ANTIGEN; CELL-ADHESION MOLECULES; GLYCOPROTEIN-3 DESMOCOLLINS; DESMOSOMAL GLYCOPROTEIN-2; CADHERIN; CHROMOSOME-18; DESMOGLEIN; CLONING; DSC2; HUMAN-CHROMOSOME-18;
Keywords:
intercellular adhesions; desmosomes; desmosomal cadherins; desmocollins; gene structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Christiano, AM Columbia Univ Coll Phys & Surg, Dept Dermatol, 630 W 168th St VC-1526, NewYork, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St VC-1526 New York NY USA 10032
Citazione:
P.B. Cserhalmi-Friedman et al., "Structural analysis reflects the evolutionary relationship between the human desmocollin gene family members", EXP DERMATO, 10(2), 2001, pp. 95-99

Abstract

Desmocollins, members of the desmosomal cadherin family, are known to playan important role in desmosomal intercellular adhesion. The human desmosomal cadherin cluster is located on chromosome 18q12, and consists of three desmoglein and three desmocollin genes. The cDNAs of all six of these genes have been cloned and sequenced, however, the exon-intron organization was reported for only one human desmocollin gene, DSC2. We elucidated the exon-intron structures of the DSC1 and DSC3 genes using PCR amplification of genomic DNA and direct sequencing of BAC clones. The results suggest a strong evolutionary conservation between the genomic organization of the desmocollin genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:44:29