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Titolo:
Participation of NH1 receptors in nociceptin-induced modulation of rat knee joint mechanosensitivity
Autore:
McDougall, JJ; Hanesch, U; Pawlak, M; Schmidt, RF;
Indirizzi:
Univ Calgary, McCaig Ctr Joint Injury & Arthrit Res, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 t Res, Calgary, AB T2N 4N1, Canada Univ Wurzburg, Inst Physiol, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 hysiol, D-97070 Wurzburg, Germany
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 137, anno: 2001,
pagine: 249 - 253
SICI:
0014-4819(200103)137:2<249:PONRIN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHANIN FQ NOCICEPTIN; SUBSTANCE-P; EXPERIMENTAL ARTHRITIS; ARTICULAR AFFERENTS; SPINAL-CORD; FQ/NOCICEPTIN; SENSITIZATION; ANTAGONIST; SYSTEM; PAIN;
Keywords:
knee joint; mechanoreceptors; neuropeptides; pain; sensory nerves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: McDougall, JJ Univ Calgary, McCaig Ctr Joint Injury & Arthrit Res, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada Univ Calgary 3330 Hosp Dr NW Calgary AB Canada T2N 4N1 anada
Citazione:
J.J. McDougall et al., "Participation of NH1 receptors in nociceptin-induced modulation of rat knee joint mechanosensitivity", EXP BRAIN R, 137(2), 2001, pp. 249-253

Abstract

Nociceptin is known to act peripherally in the rat knee joint to modulate articular mechanosensitivity and it has been postulated that neurokinin-1 (NK1) receptors may be involved in this process. To test this hypothesis, single unit extracellular recordings were made from knee joint primary afferents in response to normal and extreme rotation of the joint. Afferent firing rate was assessed following close intraarterial injection of the NK1 antagonist RP67580 followed by administration of 20 nmol nociceptin. With both normal and hyper-rotation of the knee, nociceptin was unable to elicit its usual mechanomodulatory effect such that afferent activity was not significantly different from control (P=0.7572 and P=0.9182 for normal and hyper-rotation of the joint, respectively). These data indicate that nociceptin-induced mechanosensitivity changes in the rat knee depend upon NK1 receptor activation possibly through secondary release of substance P.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:52:48