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Titolo:
Saccadic disinhibition in schizophrenia patients and their first-degree biological relatives - A parametric study of the effects of increasing inhibitory load
Autore:
Curtis, CE; Calkins, ME; Iacono, WG;
Indirizzi:
Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 sychol, Minneapolis, MN 55455 USA
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 137, anno: 2001,
pagine: 228 - 236
SICI:
0014-4819(200103)137:2<228:SDISPA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; FRONTAL EYE FIELD; MONKEY SUPERIOR COLLICULUS; ANTISACCADE PERFORMANCE; CORTICAL CONTROL; VOLUNTARY CONTROL; TASK-PERFORMANCE; FIXATION CELLS; ANTI-SACCADES; RATING-SCALE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Iacono, WG Univ Minnesota, Dept Psychol, N218 Elliott Hall,75 E River Rd, Minneapolis, MN 55455 USA Univ Minnesota N218 Elliott Hall,75 E River Rd Minneapolis MN USA 55455
Citazione:
C.E. Curtis et al., "Saccadic disinhibition in schizophrenia patients and their first-degree biological relatives - A parametric study of the effects of increasing inhibitory load", EXP BRAIN R, 137(2), 2001, pp. 228-236

Abstract

Several studies have reported that patients with schizophrenia and their relatives perform poorly on antisaccade tasks and have suggested that this deficit represents saccadic disinhibition. If this proposition is correct, then varying task parameters that specifically increase the difficulty with which unwanted saccades can be inhibited should exacerbate deficits. Forty-two schizophrenia patients, 42 of their first-degree biological relatives, 21 psychotic affective disorder patients, and 38 nonpsychiatric comparison subjects were given fixation and antisaccade tasks. The introduction of distracters and the presence of visible fixation stimuli were parameters used to vary the difficulty in suppressing unwanted saccades (inhibitory load). It is known that the presence of a fixation stimulus at the time when a saccade must be inhibited results in fewer reflexive errors on antisaccade tasks. Performance on fixation tasks without (low load) vs with distracters (high load) and antisaccade tasks that had fixation stimuli still visible (low load) vs already extinguished (high load) at the time when the reflexive saccade must be inhibited was compared. The schizophrenia patients and their first-degree biological relatives showed evidence of increased saccadic disinhibition that was most pronounced during high inhibitory load conditions. These data indicate that dysfunctional inhibitory processes, at least inthe oculomotor domain, are associated with the liability to schizophrenia. Results also suggest that this genetic liability may be related to dysfunctional prefrontal cortical areas that provide top-down inhibitory control over reflexive saccade generation.

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Documento generato il 01/06/20 alle ore 01:50:47