Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bronchoconstriction induced by inhaled adenosine 5 '-monophosphate in subjects with allergic rhinitis
Autore:
Prieto, L; Gutierrez, V; Linana, J; Marin, J;
Indirizzi:
Hosp Dr Peset, Secc Alergol, NAOMI Project, Valencia 46017, Spain Hosp Dr Peset Valencia Spain 46017 NAOMI Project, Valencia 46017, Spain
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 17, anno: 2001,
pagine: 64 - 70
SICI:
0903-1936(200101)17:1<64:BIBIA5>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLLEN-INDUCED RHINITIS; BRONCHIAL RESPONSIVENESS; ASTHMATIC SUBJECTS; MAXIMAL RESPONSE; MAST-CELLS; METHACHOLINE; HISTAMINE; RELEASE; HYPERRESPONSIVENESS; INFLAMMATION;
Keywords:
adenosine 5 '-monophosphate; airway responsiveness; allergic rhinitis; asthma; methacholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Prieto, L Hosp Dr Peset, Secc Alergol, NAOMI Project, C Gaspar Aguilar 90,Valencia 46017, Spain Hosp Dr Peset C Gaspar Aguilar 90 Valencia Spain 46017 7, Spain
Citazione:
L. Prieto et al., "Bronchoconstriction induced by inhaled adenosine 5 '-monophosphate in subjects with allergic rhinitis", EUR RESP J, 17(1), 2001, pp. 64-70

Abstract

Adenosine and its related nucleotide, adenosine 5'-monophosphate (AMP) induce bronchoconstriction in asthmatics, probably caused by histamine releasefrom airway mast cells. The objective of this study mas to determine the effect of inhaled AMP on lung function in subjects with allergic rhinitis. Atotal of 52 adults (28 subjects with allergic rhinitis, 14 asthmatics and 10 healthy subjects) were challenged with increasing concentrations of AMP and methacholine. Airflow mas assessed after each concentration and the response to each bronchoconstrictor agent was measured by the provocative concentration required to produce a 20% fall (PC20) in forced expired volume inone second (FEV1). All 14 asthmatics, 10 subjects with allergic rhinitis and none of the healthy controls mere hyperresponsive to AMP. Subjects with allergic rhinitis had higher prevalence of hyperresponsiveness to AMP than healthy controls (p=0.038). Although the prevalence of hyperresponsiveness for methacholine and for AMP in subjects with allergic rhinitis,vas similar(39% and 36%, respectively), four subjects had hyperresponsiveness to methacholine but not to AMP,,whereas three subjects had hyperresponsiveness to AMP but not to methacholine. To conclude, inhaled adenosine 5'-monophosphate causes airway narrowing in a significantly higher proportion of subjects with allergic rhinitis than healthy volunteers. Furthermore, methacholine and adenosine 5'-monophosphate hyperresponsiveness are not detected in the same individuals with allergic rhinitis, thus suggesting that responsivenessto the two bronchoconstrictor stimuli is not reflecting the same abnormalities of the airways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 21:26:16