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Titolo:
Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics
Autore:
Fukunaga, K; Asano, K; Mao, XQ; Gao, PS; Roberts, MH; Oguma, T; Shiomi, T; Kanazawa, M; Adra, CN; Shirakawa, T; Hopkin, JM; Yamaguchi, K;
Indirizzi:
Keio Univ, Sch Med, Dept Med, Cardiopulm Div,Shinju Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 iopulm Div,Shinju Ku, Tokyo 1608582, Japan Univ Wales, Expt Med Unit, Swansea, W Glam, Wales Univ Wales Swansea W Glam Wales s, Expt Med Unit, Swansea, W Glam, Wales Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USAHarvard Univ Boston MA USA 02215 s Med Ctr, Sch Med, Boston, MA 02215 USA
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 1, volume: 17, anno: 2001,
pagine: 59 - 63
SICI:
0903-1936(200101)17:1<59:GPOCCR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EOSINOPHIL EOTAXIN RECEPTOR; GENOME-WIDE SEARCH; SUSCEPTIBILITY LOCI; MOLECULAR-CLONING; HIV-1 INFECTION; EXPRESSION; CELLS; HYPERRESPONSIVENESS; ASSOCIATION; INDIVIDUALS;
Keywords:
association; atopy; chromosome 3; house dust mite; immunoglobulin E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Asano, K Keio Univ, Sch Med, Dept Med, Cardiopulm Div,Shinju Ku, 35 Shinanomachi, Tokyo 1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582kyo 1608582, Japan
Citazione:
K. Fukunaga et al., "Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics", EUR RESP J, 17(1), 2001, pp. 59-63

Abstract

Whole genome scan analyses have revealed that chromosomal region 3p21-24, which contains a gene cluster of CC chemokine receptors such as CCR3, is possibly linked to asthma. Because CCR3 ligands play a pivotal role in the selective recruitment and activation of inflammatory cells in the asthmatic airway, the authors examined whether there is any association between asthmaand the CCR3 gene polymorphisms. Three polymorphisms mere identified using the single stranded conformational polymorphism method in Japanese (Asian) and British (Caucasian) subjects; one silent mutation T51C and two missense mutations G824A and T971C. These polymorphisms were examined in 391 Japanese subjects (210 asthmatics and 181 nonasthmatic controls) and 234 British subjects (142 asthmatics and 92 nonasthmatic controls). Asthma diagnosis was based on episodic symptoms, documented wheeze, and the presence of reversible airflow limitation. CCR3 T51C demonstrated a significant association with the diagnosis of asthma in the British population (odds ratio 2.35, p<0.01), but not in the Japanese population. Multiple logistic regression analysis also showed that CCR3 T51C was associated with asthma (odds ratio 2.83, p< 0.02), independent of atopic phenotypes such as high levels of total or house dust mite-specific immunoglobulin-E in serum. In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:12:10