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Titolo:
Can nootropic drugs be effective against the impact of ethanol teratogenicity on cognitive performance?
Autore:
Vaglenova, J; Petkov, VV;
Indirizzi:
Bulgarian Acad Sci, Inst Physiol, Lab Expt Psychopharmacol, BU-1113 Sofia,Bulgaria Bulgarian Acad Sci Sofia Bulgaria BU-1113 rmacol, BU-1113 Sofia,Bulgaria
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 33 - 40
SICI:
0924-977X(200102)11:1<33:CNDBEA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT DISORDER; ALCOHOL EXPOSURE; RAT HIPPOCAMPUS; PIRACETAM; METHYLPHENIDATE; ANIRACETAM; RECEPTOR; MEMORY; BRAIN; BINDING;
Keywords:
prenatal ethanol exposure; fetal alcohol effects; learning; memory; nootropic drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Vaglenova, J Auburn Univ, Dept Pharmacal Sci, 401 Pharm Bldg, Auburn, AL 36849 USA Auburn Univ 401 Pharm Bldg Auburn AL USA 36849 , AL 36849 USA
Citazione:
J. Vaglenova e V.V. Petkov, "Can nootropic drugs be effective against the impact of ethanol teratogenicity on cognitive performance?", EUR NEUROPS, 11(1), 2001, pp. 33-40

Abstract

Rats exposed pre- (PA) and postnatally (PNA) to ethanol at a dose of 1 g/kg for 24 h developed fetal alcohol effects (FAE). This was measured using acondition-reflex method for active avoidance with punishment reinforcement(shuttle-box) in which pronounced learning and memory deficits in 3-month-old rats were found after ethanol exposure (Vaglenova and Petkov, 1998. Fetal alcohol effects in rats exposed pre- and postnatally to a low dose of ethanol. Alcohol. Clin. Exp. Res. 22(3), 697-703). In the present study the effects of piracetam (Pyramem) at a dose of 600 mg/kg body weight, aniracetam at 50 mg/kg, and meclophenoxate (Centrophenoxine) at 100 mg/kg were studied. The drugs were administered orally during 10 days to separate groups ofnaive and pre- and postnatally exposed to ethanol rats. All the investigated nootropic drugs showed a significant possibility to alleviate learning and memory disability of rats with FAE. Aniracetam was administered to 1-month-old rats, demonstrating a prolonged (2 months) therapeutic effect, observed in rats aged 3 months. As previously reported (Vaglenova and Petkov, 1998), between male rats with FAE and controls, 66 and 33% were 'poor learners', respectively. In all nootropic treatment groups the percentage of 'poorlearners' dropped to 28%. The positive effects of piracetam, aniracetam and meclophenoxate suggest that these drugs could be used for both treatment and prophylactic of FAE-connected disturbances of cognition. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 28/01/20 alle ore 20:52:26