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Titolo:
New onset diabetes and atypical antipsychotics
Autore:
Liebzeit, KA; Markowitz, JS; Caley, CF;
Indirizzi:
Med Univ S Carolina, Inst Psychiat, Dept Pharmaceut Sci, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 Sci, Charleston, SC 29425 USA Med Univ S Carolina, Coll Pharm, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 arm, Charleston, SC 29425 USA Burlingame Ctr Psychiat Res & Educ, Hartford, CT USA Burlingame Ctr Psychiat Res & Educ Hartford CT USA duc, Hartford, CT USA Univ Connecticut, Sch Pharm, Storrs, CT USA Univ Connecticut Storrs CT USA iv Connecticut, Sch Pharm, Storrs, CT USA
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 25 - 32
SICI:
0924-977X(200102)11:1<25:NODAAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED GLUCOSE-TOLERANCE; SERUM TRIGLYCERIDE LEVELS; CLOZAPINE TREATMENT; WEIGHT-GAIN; OLANZAPINE TREATMENT; PLASMA-GLUCOSE; KETOACIDOSIS; MELLITUS; HYPERGLYCEMIA; SCHIZOPHRENIA;
Keywords:
new onset diabetes; antipsychotics; typical and atypical;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Markowitz, JS Med Univ S Carolina, Inst Psychiat, Dept Pharmaceut Sci, Rm 338N,67 President St,POB 250861, Charleston, SC 29425 USA Med Univ S Carolina Rm 338N,67 President St,POB 250861 Charleston SC USA 29425
Citazione:
K.A. Liebzeit et al., "New onset diabetes and atypical antipsychotics", EUR NEUROPS, 11(1), 2001, pp. 25-32

Abstract

As a class, the atypical antipsychotics are the first line treatment choice for the psychopharmacologic management of psychotic disorders. Emerging evidence currently suggests that at least two of the atypical antipsychotics, clozapine and olanzapine, and possibly quetiapine may be associated with the risk of new onset diabetes or serum glucose dyscontrol. Computerized Medline and Current Contents searches from years 1966 through June 2000 were undertaken to retrieve all pertinent studies and case reports of typical and atypical antipsychotics and glucose-insulin problems. Historically, both schizophrenia and the older antipsychotics medications have been reported to be associated with a similar risk for causing disruptions in serum glucose control. Additionally, diabetes has well recognized associations with a number of medical disorders such as cardiovascular disease; it is therefore worthy of attention. Hypothesized mechanisms for antipsychotic induced diabetes ranges from the antagonism of several neurotransmitter receptors to insulin resistance. A total of thirty-five cases of induced or exacerbated diabetes are presently available in the published literature; the vast majority of cases implicate clozapine (n=20) and olanzapine (n=15). In multiple cases, diabetic ketoacidosis has been the presenting symptom; daily atypicalantipsychotic doses have been within acceptable ranges and were not considered to be excessive. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 23/01/20 alle ore 07:15:00