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Titolo:
Dietary oleoyl-estrone delays the growth rate of young rats
Autore:
Tang, V; Torregrosa, C; Remesar, X; Alemany, M;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Ctr Especial Recerca Nutr & Ciencia Aliments, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 liments, E-08028 Barcelona, Spain
Titolo Testata:
EUROPEAN JOURNAL OF NUTRITION
fascicolo: 1, volume: 40, anno: 2001,
pagine: 17 - 22
SICI:
1436-6207(200102)40:1<17:DODTGR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE ZUCKER RATS; SHORT-TERM TREATMENT; CAFETERIA DIET; LIPOSOMES MERLIN-2; BODY-WEIGHT; WISTAR RATS; OB GENE; NITROGEN; EXPRESSION; BALANCES;
Keywords:
growth; oleoyl-estrone; nitrogen balance; energy balance; leptin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Alemany, M Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Ctr EspecialRecerca Nutr & Ciencia Aliments, Av Diagonal 645, E-08028 Barcelona, SpainUniv Barcelona Av Diagonal 645 Barcelona Spain E-08028 , Spain
Citazione:
V. Tang et al., "Dietary oleoyl-estrone delays the growth rate of young rats", EUR J NUTR, 40(1), 2001, pp. 17-22

Abstract

Background Oleoylestrone administration induces the rapid loss of fat preserving body protein. Aim of the study We intended to check whether the fat-shedding effect of oleoyl-estrone arrests growth in young rats,limiting thebuildup of protein and fat. Methods Oleoyl-estrone diluted in a powdered hyperlipidic diet (33 mu mol/kg) was given for 30 days to 30-day old Zucker lean (Fa/?) rats. Their body weight and food consumption were followed daily; on day 30 of treatment (60-day old rats), whole body composition (lipid,protein) was determined, and plasma energy parameters and leptin were measured. Results Oleoyl-estrone-treated rats grew more slowly than controls fed the hyperlipidic diet alone, and on day 60 their lipid content was about half that of controls. Protein content per kg was identical in both groups,but treated rats tended to accumulate less nitrogen and energy because of their smaller size. No changes in plasma glucose, urea, triacylglycerols ortotal cholesterol were observed, but oleoylestrone-treated rats showed lower circulating leptin than controls. Conclusion Despite limiting the accumulation of lipids, oleoyl-estrone slowed, but did not arrest growth of youngrats, nor elicit a loss of fat or protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:41:05