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Titolo:
Validation of myocardial blood flow estimation with nitrogen-13 ammonia PET by the argon inert gas technique in humans
Autore:
Kotzerke, J; Glatting, G; van den Hoff, J; Hoher, M; Neumaier, B; Wohrle, J; Reske, SN;
Indirizzi:
Univ Ulm, Dept Nucl Med, D-89081 Ulm, Germany Univ Ulm Ulm Germany D-89081 iv Ulm, Dept Nucl Med, D-89081 Ulm, Germany Univ Ulm, Dept Cardiol, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Dept Cardiol, Ulm, Germany Hannover Med Sch, Dept Nucl Med, D-3000 Hannover, Germany Hannover Med Sch Hannover Germany D-3000 l Med, D-3000 Hannover, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 28, anno: 2001,
pagine: 340 - 345
SICI:
0340-6997(200103)28:3<340:VOMBFE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; N-13 AMMONIA; NONINVASIVE QUANTIFICATION; PERFUSION; DISEASE; RESERVE; REGION;
Keywords:
argon; nitrogen-13 ammonia; positron emission tomography; myocardial blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kotzerke, J Univ Ulm, Dept Nucl Med, Robert Koch Str 8, D-89081 Ulm, Germany Univ Ulm Robert Koch Str 8 Ulm Germany D-89081 1 Ulm, Germany
Citazione:
J. Kotzerke et al., "Validation of myocardial blood flow estimation with nitrogen-13 ammonia PET by the argon inert gas technique in humans", EUR J NUCL, 28(3), 2001, pp. 340-345

Abstract

We simultaneously determined global myocardial blood flow (MBF) by the argon inert gas technique and by nitrogen-13 ammonia positron emission tomography (PET) to validate PET-derived MBF values in humans. A total of 19 patients were investigated at rest (n=19) and during adenosine-induced hyperaemia (n=16). Regional coronary artery stenoses were ruled out by angiography. The argon inert gas method uses the difference of arterial and coronary sinus argon concentrations during inhalation of a mixture of 75% argon and 25%oxygen to estimate global MBE. It can be considered as valid as the microspheres technique, which, however, cannot be applied in humans. Dynamic PET was performed after injection of 0.8 +/-0.2 GBq N-13-ammonia and MBF was calculated applying a two-tissue compartment model. MBF values derived from the argon method at rest and during the hyperaemic state were 1.03 +/-0.24 ml min(-1) g(-1) and 2.64 +/-1.02 ml min-(1) g-(1), respectively. MBF valuesderived from ammonia PET at rest and during hyperaemia were 0.95 +/-0.23 ml min(-1) g(-1) and 2.44 +/-0.81 ml min(-1) g(-1), respectively. The correlation between the two methods was close (y=0.92x+0.14, r=0.96; P<0.0001). No indication was found for limited extraction of ammonia in the myocardium. The high concordance of global MBF values derived with argon and ammonia indicates that the implicit correction of spillover and recovery effects, incorporated in the model by including an effective blood volume parameter, works correctly quantitatively. Our data provide the previously missing human validation of MBF measurements from N-13-ammonia PET.

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Documento generato il 19/01/20 alle ore 14:35:15