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Titolo:
Use of [C-11]acetate and [O-15]O-2 PET for the assessment of myocardial oxygen utilization in patients with chronic myocardial infarction
Autore:
Ukkonen, H; Knuuti, J; Katoh, C; Iida, H; Sipila, H; Lehikoinen, P; Nagren, K; Voipio-Pulkki, LM;
Indirizzi:
Turku Univ Hosp, Dept Med, FIN-20521 Turku, Finland Turku Univ Hosp Turku Finland FIN-20521 pt Med, FIN-20521 Turku, Finland Turku PET Ctr, FIN-20521 Turku, Finland Turku PET Ctr Turku Finland FIN-20521 PET Ctr, FIN-20521 Turku, Finland Hokkaido Univ, Sch Med, Dept Tracer Kinet, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 et, Sapporo, Hokkaido 060, Japan Natl Cardiovasc Res Ctr, Inst Res, Dept Investigat Radiol, Osaka, Japan Natl Cardiovasc Res Ctr Osaka Japan ept Investigat Radiol, Osaka, Japan Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland Univ Helsinki Helsinki Finland , Cent Hosp, Dept Med, Helsinki, Finland
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 28, anno: 2001,
pagine: 334 - 339
SICI:
0340-6997(200103)28:3<334:UO[A[P>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; REGIONAL BLOOD-FLOW; OXIDATIVE-METABOLISM; C-11 ACETATE; ERROR ANALYSIS; CORONARY REVASCULARIZATION; NONINVASIVE QUANTIFICATION; GLUCOSE-UTILIZATION; O-15(2) INHALATION; INPUT FUNCTION;
Keywords:
myocardial infarction; metabolism; oxygen; tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ukkonen, H Turku Univ Hosp, Dept Med, POB 52, FIN-20521 Turku, Finland Turku Univ Hosp POB 52 Turku Finland FIN-20521 Turku, Finland
Citazione:
H. Ukkonen et al., "Use of [C-11]acetate and [O-15]O-2 PET for the assessment of myocardial oxygen utilization in patients with chronic myocardial infarction", EUR J NUCL, 28(3), 2001, pp. 334-339

Abstract

Carbon-11 acetate positron emission tomography (PET) has been widely used to assess regional oxidative metabolism of the heart. However, the accuracyof [C-11]acetate PET in assessing oxidative metabolism in infarcted myocardium remains controversial. Thirteen patients with stable coronary artery disease and old myocardial infarction were studied. The O-15-based PET studies yielded regional blood flow (rMBF, ml/min/g) and oxygen consumption (rMMRO(2), ml/min/g), which was compared with the myocardial clearance rate constant (k(mono)) of [C-11]acetate in segments with rMBF greater than or equal to 75% (group A), 50%-74% (group B) or <50% (group C) of the normal reference segment. Mean MBF was 0.96<plus/minus>0.08 ml/g/min in group A, 0.67 +/-0.06 ml/g/min in group B and 0.42 +/-0.07 ml/g/min in group C segments. The segmental rMMRO(2) correlated linearly with k(mono) (r=0.89, P<0.001, y=0.61x+0.026). The k(mono)/rMMRO(2) ratio was comparable in the group A and B segments (0.99<plus/minus>0.19 vs 1.07 +/-0.21, P=NS). However, the ratiowas significantly higher in the group C segments (1.28 +/-0.35, P=0.037). It is concluded that k(mono) of [C-11]acetate correlates linearly with rMMRO(2) determined by [O-15]O-2 inhalation. However, k(mono) appears to yield higher rMMRO(2) estimates than the [O-15]O-2 method in low-flow areas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:40:54