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Titolo:
Diagnosis of recurrent head and neck squamous cell carcinoma with 3-[I-123]iodo-L-alpha-methyltyrosine SPET
Autore:
Dierickx, LO; Lahoutte, T; Deron, P; Caveliers, V; Vanhove, C; Everaert, H; Bossuyt, A;
Indirizzi:
Free Univ Brussels, Akad Ziekenhuis, Dept Nucl Med, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 Med, B-1090 Brussels, Belgium Free Univ Brussels, Acad Ziekenhuis, Aspriant FWO Vlaanderen, Brussels, Belgium Free Univ Brussels Brussels Belgium t FWO Vlaanderen, Brussels, Belgium Free Univ Brussels, Acad Ziekenhuis, Dept Otorhinolaryngol Head & Neck Surg, Brussels, Belgium Free Univ Brussels Brussels Belgium Head & Neck Surg, Brussels, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 28, anno: 2001,
pagine: 282 - 287
SICI:
0340-6997(200103)28:3<282:DORHAN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; BRAIN-TUMORS; IODINE-123-ALPHA-METHYL TYROSINE; COMPUTED-TOMOGRAPHY; CANCER; PET; FLUORODEOXYGLUCOSE; RADIOTHERAPY; I-123; FLUORINE-18-FLUORODEOXYGLUCOSE;
Keywords:
3-[I-123]iodo-L-alpha-Methyltyrosine; head and neck cancer; tumour recurrence; single-photon emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Dierickx, LO Free Univ Brussels, Akad Ziekenhuis, Dept Nucl Med, Laarbeeklaan 101, B-1090 Brussels, Belgium Free Univ Brussels Laarbeeklaan 101 Brussels Belgium B-1090
Citazione:
L.O. Dierickx et al., "Diagnosis of recurrent head and neck squamous cell carcinoma with 3-[I-123]iodo-L-alpha-methyltyrosine SPET", EUR J NUCL, 28(3), 2001, pp. 282-287

Abstract

The distribution of [I-123]iodo-L-alpha -methyltyrosine (I-123-3-IMT) in the tumour region of 21 patients with clinically suspected recurrent squamous cell head and neck carcinoma was studied. Single-photon emission tomography (SPET) imaging of the head and neck region was performed 10 min after the injection of 130-170 MBq I-123-3-IMT using a dual-detector gamma camera. Images were interpreted visually and classified as positive or negative forrecurrent disease. In addition, target to background ratios (T/B) were measured using semi-automated region of interest analysis. IMT-SPET results were compared with the data derived from clinicopathological follow-up. IMT-SPET detected recurrent disease in 14 of 15 patients (sensitivity 93%). T/B ratios ranged between 1.5 and 2.4 (mean 1.88). One patient with a small tumour (1.2 cm) had a false-negative result. This is attributed to the limitedspatial resolution of the SPET system. Five of six patients were correctlydiagnosed to be negative for tumour recurrence. T/B ratios ranged between 1.2 and 1.4 (mean 1.30). In one patient IMT-SPET was positive without evidence of recurrence based on clinicopathological follow up. This finding was probably due to uptake into inflammatory tissue. IMT-SPET appears to be a sensitive tool (93%) for the detection of recurrent head and neck squamous cell carcinoma. Further studies with I-123-3-IMT as a metabolic tracer for the detection of head and neck cancer recurrence using SPET are recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/01/21 alle ore 06:44:02