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Titolo:
Vasoactive intestinal polypeptide (VIP) phase-shifts the rat suprachiasmatic nucleus clock in vitro
Autore:
Reed, HE; Meyer-Spasche, A; Cutler, DJ; Coen, CW; Piggins, HD;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Univ London Kings Coll, Neurosci Res Ctr, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL r, London SE1 1UL, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 839 - 843
SICI:
0953-816X(200102)13:4<839:VIP(PT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING PEPTIDE; RECEPTOR MESSENGER-RNA; GASTRIN-RELEASING PEPTIDE; RETINOHYPOTHALAMIC TRACT; CIRCADIAN CHANGES; PHOTIC REGULATION; BIOLOGICAL CLOCK; IN-VITRO; GLUTAMATE; PACAP;
Keywords:
brainslice; circadian rhythm; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Piggins, HD Univ Manchester, Sch Biol Sci, Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester Oxford Rd Manchester Lancs England M13 9PT and
Citazione:
H.E. Reed et al., "Vasoactive intestinal polypeptide (VIP) phase-shifts the rat suprachiasmatic nucleus clock in vitro", EUR J NEURO, 13(4), 2001, pp. 839-843

Abstract

In mammals, the principal circadian pacemaker is housed in the hypothalamic suprachiasmatic nuclei (SCN). The SCN exhibit high levels of vasoactive intestinal polypeptide (VIP) immunoreactivity and two of the three VIP receptors, VPAC(2) and PAC(1), are found in the rat SCN. However, the role of VIP in the SCN remains unclear. In this study, we examined the phase-resetting actions of VIP and selective VIP receptor agonists on the electrical activity rhythm of rat SCN neurons in vitro. Application of VIP during the subjective day did not shift the peak in the firing rate rhythm. However, VIP treatment during the early or late subjective night evoked a small phase delay or a large phase advance, respectively. The phase-advancing effect of VIP was reproduced by the novel VPAC(2) receptor agonist RO 25-1553, but not by pituitary adenylate cyclase-activating peptide (a potent PAC(1) receptoragonist), or by [K15,R16,L27]VIP(1-7)/GRF(8-27), a novel, selective VPAC(1) receptor agonist. These data show that VIP phase-dependently phase-resetsthe rodent SCN pacemaker in vitro, presumably via the VPAC(2) receptor. Asthe pattern of phase-shifting evoked by VIP and RO 25-1553 resembles the phase-resetting actions of light on rodent behavioural rhythms, these data support a role for VIP and the VPAC(2) receptor in photic entrainment of therodent circadian pacemaker.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:34:04