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Titolo:
Novelty-evoked elevations of nucleus accumbens dopamine: dependence on impulse flow from the ventral subiculum and glutamatergic neurotransmission inthe ventral tegmental area
Autore:
Legault, M; Wise, RA;
Indirizzi:
Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada Concordia Univ Montreal PQ Canada H3G 1M8 l, Montreal, PQ H3G 1M8, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 819 - 828
SICI:
0953-816X(200102)13:4<819:NEONAD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACRANIAL SELF-STIMULATION; INVIVO PRESYNAPTIC CONTROL; CAT CAUDATE-NUCLEUS; PREFRONTAL CORTEX; HIPPOCAMPAL DAMAGE; LOCOMOTOR-ACTIVITY; INVESTIGATORY EXPLORATION; EXTRACELLULAR DOPAMINE; BEHAVIORAL REACTIONS; ANTIPSYCHOTIC-DRUGS;
Keywords:
schizophrenia; microdialysis; hippocampus; tetrodotoxin; kynurenic acid; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Legault, M Univ Montreal, Ctr Rech Fernand Seguin, 7331 Hochelaga, Montreal, PQ H1N 3V2, Canada Univ Montreal 7331 Hochelaga Montreal PQ Canada H1N 3V2 Canada
Citazione:
M. Legault e R.A. Wise, "Novelty-evoked elevations of nucleus accumbens dopamine: dependence on impulse flow from the ventral subiculum and glutamatergic neurotransmission inthe ventral tegmental area", EUR J NEURO, 13(4), 2001, pp. 819-828

Abstract

In vivo microdialysis in freely moving rats was used to monitor novelty-evoked elevations in extracellular dopamine in the nucleus accumbens septi (NAS) and to examine the role of the ventral subiculum of the hippocampus andglutamatergic transmission in the ventral tegmental area (VTA) on these elevations. Exposure to novel stimuli evoked investigatory activity and increased nucleus accumbens dopamine. Unilateral injections of the sodium channel blocker tetrodotoxin (0.16 ng/0.5 muL) into the ventral subiculum ipsilateral to the dialysed NAS abolished novelty-evoked elevations in dopamine. Injections of tetrodotoxin into the contralateral VS did not prevent novelty-evoked elevations in nucleus accumbens dopamine. Unilateral perfusion (viamicrodialysis) of the ionotropic glutamate receptor antagonists kynurenic acid (1 mm) into the ipsilateral but not the contralateral VTA blocked novelty-evoked elevations in nucleus accumbens dopamine. Neither unilateral injections of tetrodotoxin nor unilateral perfusion of kynurenic acid disrupted investigatory behaviour. These data indicate that phasic elevations in nucleus accumbens dopamine evoked by exposure to unconditioned novel stimuli are dependent on impulse flow from the hippocampus and glutamatergic transmission in the VTA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:02:46