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Titolo:
In vitro effects of acetyl-DL-leucine (tanganil (R)) on central vestibularneurons and vestibulo-ocular networks of the guinea-pig
Autore:
Vibert, N; Vidal, PP;
Indirizzi:
Univ Paris 05, CNRS, Lab Neurobiol Reseaux Sensorimoteurs, F-75270 Paris 06, France Univ Paris 05 Paris France 06 x Sensorimoteurs, F-75270 Paris 06, France Univ Paris 07, ESA 7060, F-75270 Paris, France Univ Paris 07 Paris France F-75270 s 07, ESA 7060, F-75270 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 735 - 748
SICI:
0953-816X(200102)13:4<735:IVEOA(>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM SLICES; INTRINSIC MEMBRANE-PROPERTIES; IN-VITRO; NUCLEUS NEURONS; COMPENSATION; RECOVERY; LABYRINTHECTOMY; MECHANISMS; PATHWAYS; SYSTEM;
Keywords:
balance control; electrophysiology; unilateral labyrinthectomy; vertigo crisis; vestibular nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Vibert, N Univ Paris 05, CNRS, Lab Neurobiol Reseaux Sensorimoteurs, 45 Rue St Peres, F-75270 Paris 06, France Univ Paris 05 45 Rue St Peres Paris France 06 Paris 06, France
Citazione:
N. Vibert e P.P. Vidal, "In vitro effects of acetyl-DL-leucine (tanganil (R)) on central vestibularneurons and vestibulo-ocular networks of the guinea-pig", EUR J NEURO, 13(4), 2001, pp. 735-748

Abstract

For 40 years, the amino acid acetyl-DL-leucine (or isoleucine/Tanganil(R))has been used in clinical practice to reduce the imbalance and autonomic signs associated with acute vertigo crises. In animal models, acetyl-DL-leucine was shown to accelerate vestibular compensation following unilateral labyrinthectomy, while having only minor effects on normal vestibular function. However, the underlying mechanisms are unknown. In this study, the effect of acetyl-DL-leucine on the activity of central vestibular neurons of themedial vestibular nucleus (MVN) and/or the overall activity of vestibular-related networks was electrophysiologically measured in brainstem slices and in the isolated, in vitro whole brain (IWB) of guinea-pig. Only moderate effects were obtained in normal animals, where both excitatory and inhibitory actions of acetyl-DL-leucine were obtained. However, intracellular recordings from MVN neurons revealed that the nature of the response depended onthe resting membrane potential. The neurons excited by acetyl-DL-leucine were significantly hyperpolarized compared to nonsensitive cells, whereas the neurons inhibited by this compound tended to display higher than normal membrane potentials. In accordance with these data, acetyl-DL-leucine reduced the prominent asymmetry characterizing the vestibular-related networks ofIWBs taken from previously labyrinthectomized animals, by decreasing the activity of the abnormally depolarized neurons on the hyperactive side. Altogether, our results suggest that acetyl-DL-leucine might act mainly on abnormally hyperpolarized and/or depolarized MVN neurons, by bringing back their membrane potential towards a mean value of -65 to -60 mV. Since in animalmodels, acute vestibular disorders are associated with asymmetrical spontaneous activities of MVN neurons, this study suggests how acetyl-DL-leucine may reduce acute, vestibular-related imbalances in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:10:15