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Titolo:
Enhanced CREB phosphorylation in immature dentate gyrus granule cells precedes neurotrophin expression and indicates a specific role of CREB in granule cell differentiation
Autore:
Bender, RA; Lauterborn, JC; Gall, CM; Cariaga, W; Baram, TZ;
Indirizzi:
Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 t & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Paediat, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Dept Paediat, Irvine, CA 92697 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 679 - 686
SICI:
0953-816X(200102)13:4<679:ECPIID>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; ELEMENT-BINDING PROTEIN; DEVELOPING RAT-BRAIN; SYNAPTIC PLASTICITY; TRANSCRIPTION FACTORS; ADULT NEUROGENESIS; GENE-EXPRESSION; SELECTIVE VULNERABILITY; SEIZURE ACTIVITY; MOSSY FIBERS;
Keywords:
development; hippocampus; neurogenesis; rat; transcription factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Baram, TZ Univ Calif Irvine, Dept Anat & Neurobiol, Med Sci I,4475, Irvine, CA 92697USA Univ Calif Irvine Med Sci I,4475 Irvine CA USA 92697 CA 92697USA
Citazione:
R.A. Bender et al., "Enhanced CREB phosphorylation in immature dentate gyrus granule cells precedes neurotrophin expression and indicates a specific role of CREB in granule cell differentiation", EUR J NEURO, 13(4), 2001, pp. 679-686

Abstract

Differentiation and maturation of dentate gyrus granule cells requires coordinated interactions of numerous processes. These must be regulated by protein factors capable of integrating signals mediated through diverse signalling pathways. Such integrators of inter and intracellular physiological stimuli include the cAMP-response element binding protein (CREB), a leucine-zipper class transcription factor that is activated through phosphorylation. Neuronal activity and neurotrophic factors, known to be involved in granule cell differentiation, are major physiologic regulators of CREB function. To examine whether CREB may play a role in governing coordinated gene transcription during granule cell differentiation, we determined the spatial andtemporal profiles of phosphorylated (activated) CREB throughout postnatal development in immature rat hippocampus. We demonstrate that CREB activation is confined to discrete, early stages of granule cell differentiation. Inaddition, CREB phosphorylation occurs prior to expression of the neurotrophins BDNF and NT-3. These data indicate that in a signal transduction cascade connecting CREB and neurotrophins in the process of granule cell maturation, CREB is located upstream of neurotrophins. Importantly, CREB may be a critical component of the machinery regulating the coordinated transcription of genes contributing to the differentiation of granule cells and their integration into the dentate gyrus network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:47:01