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Titolo:
GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivationalsystems
Autore:
Laviolette, SR; van der Kooy, D;
Indirizzi:
Univ Toronto, Dept Anat, Neurobiol Res Grp, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 s Grp, Toronto, ON M5S 1A8, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 1009 - 1015
SICI:
0953-816X(200103)13:5<1009:GRITVT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUAL-PROBE MICRODIALYSIS; NUCLEUS-ACCUMBENS; RAT-BRAIN; 6-HYDROXYDOPAMINE LESIONS; NEURONS; NEUROLEPTICS; MUSCIMOL; BINDING; RELEASE; PHARMACOLOGY;
Keywords:
dopamine; GABA; reward systems; ventral tegmental area; wistar rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Laviolette, SR Univ Toronto, Dept Anat, Neurobiol Res Grp, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto 1 Kings Coll Circle Toronto ON Canada M5S 1A8
Citazione:
S.R. Laviolette e D. van der Kooy, "GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivationalsystems", EUR J NEURO, 13(5), 2001, pp. 1009-1015

Abstract

In the midbrain ventral tegmental area (VTA), both dopaminergic and nondopaminergic neural substrates mediate various behavioural reward phenomena. VTA GABAergic neurons are anatomically positioned to influence the activity of both the mesolimbic dopamine system and nondopamine efferents from the VTA. In order to examine the possible functional role of VTA GABA(A) receptors in neural reward processes, we performed discrete, bilateral microinjections of the GABA(A) receptor agonist, muscimol, or the GABA(A) receptor antagonist, bicuculline, into the VTA. Using a fully counterbalanced, unbiasedconditioned place-preference paradigm, we demonstrate that activation of VTA GABA(A) receptors, with the GABA(A) receptor agonist muscimol (5-50 ng/muL), or inhibition of VTA GABA(A) receptors, with the GABA(A) receptor antagonist bicuculline (5-50 ng/muL), both produce robust rewarding effects. Furthermore, these rewarding effects can be pharmacologically dissociated: blockade of dopamine receptors with a dopamine receptor antagonist, alpha -flupenthixol (0.8 mg/kg; i.p.), or concurrent activation of VTA GABA(B) receptors with a GABA(B) receptor agonist, baclofen (70 ng/muL), blocked the rewarding properties of the GABA(A) receptor agonist, but had no effect on therewarding properties of the GABA(A) receptor antagonist. These results suggest that, within the VTA, a single GABA(A) receptor substrate controls bidirectional reward signalling between dopaminergic and nondopaminergic brainreward systems.

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Documento generato il 18/01/20 alle ore 07:29:27