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Titolo:
The D-2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
Autore:
Dockstader, CL; Rubinstein, M; Grandy, DK; Low, MJ; van der Kooy, D;
Indirizzi:
Univ Toronto, Dept Anat & Cell Biol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 Biol, Toronto, ON M5S 1A8, Canada Univ Buenos Aires, Dept Biol, CONICET, Inst Invest Ingn Genet & Biol Mol, Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina Buenos Aires, DF, Argentina Oregon Hlth Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97035 USA Oregon Hlth Sci Univ Portland OR USA 97035 rmacol, Portland, OR 97035 USA Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97035 USA Oregon Hlth Sci Univ Portland OR USA 97035 m Inst, Portland, OR 97035 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 995 - 1001
SICI:
0953-816X(200103)13:5<995:TDRICI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE D2 RECEPTORS; INBRED MOUSE STRAINS; BEHAVIORAL PHENOTYPES; LOCOMOTOR-ACTIVITY; BRAIN-STIMULATION; GENE-EXPRESSION; DEFICIENT MICE; RAT STRIATUM; DRUG-NAIVE; REWARD;
Keywords:
backcrossing; D-2; dopamine; drug abuse; knockout mice; motivation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Dockstader, CL Univ Toronto, Dept Anat & Cell Biol, 100 Coll St, Toronto, ON M5S 1A8, Canada Univ Toronto 100 Coll St Toronto ON Canada M5S 1A8 , Canada
Citazione:
C.L. Dockstader et al., "The D-2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice", EUR J NEURO, 13(5), 2001, pp. 995-1001

Abstract

According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived state (i.e. previously drug-naive). To determine the role of the D-2 dopamine receptor subtype in mediating opiate motivation, we examined the behaviour of N5 congenic D-2 receptor knockout mice and their wild-type siblings in opiate-naive and opiate-dependent and withdrawn place conditioning paradigms. Opiate-naive D-2 receptor knockout mice demonstrated acquisition ofmorphine-conditioned place preference but failed to acquire place preference when conditioned in the deprived state. We propose that D-2 receptor function is critical in mediating the motivational effects of opiates only when the animal is in an opiate-dependent and withdrawn motivational state. These findings also underscore the important influence of the genetic background to a given phenotype, as evidenced by the observation that increasing the allelic contribution from the 129/SvJ strain abolishes morphine place preference in C57BL/6 wild-type mice.

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Documento generato il 31/03/20 alle ore 03:43:50