Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Fibroblast growth factor-2 is selectively modulated in the rat brain by E-5842, a preferential sigma-1 receptor ligand and putative atypical antipsychotic
Autore:
Ovalle, S; Zamanillo, D; Andreu, F; Farre, AJ; Guitart, X;
Indirizzi:
Labs Esteve SA, Dept Neuropharmacol, Res Ctr, Barcelona 08041, Spain Labs Esteve SA Barcelona Spain 08041 ol, Res Ctr, Barcelona 08041, Spain
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 909 - 915
SICI:
0953-816X(200103)13:5<909:FGFISM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; DOPAMINERGIC-NEURONS; FOS EXPRESSION; CLOZAPINE; SCHIZOPHRENIA; FOREBRAIN; HYPOFRONTALITY; HALOPERIDOL; ACTIVATION; INDUCTION;
Keywords:
gene regulation; negative symptoms; neuroleptic; polymerase chain reaction; prefrontal cortex; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Guitart, X Labs Esteve SA, Dept Neuropharmacol, Res Ctr, Verge de Montserrat 221, Barcelona 08041, Spain Labs Esteve SA Verge de Montserrat 221 Barcelona Spain 08041 n
Citazione:
S. Ovalle et al., "Fibroblast growth factor-2 is selectively modulated in the rat brain by E-5842, a preferential sigma-1 receptor ligand and putative atypical antipsychotic", EUR J NEURO, 13(5), 2001, pp. 909-915

Abstract

Fibroblast growth factor-2 (FGF-2) is a member of a large family of trophic factors whose expression is regulated under several conditions in different areas of the brain. The goal of our experiments was to determine whetherthe administration of 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-[4-(1,2,4-triazol-1-il)butyl] pyridine citrate (E-5842), a sigma-1 receptor ligand and putative atypical antipsychotic, could regulate the expression of FGF-2. After chronic treatment with E-5842 (21 days, and the animals killed 24 h after the last administration), an up-regulation was observed of the expression of FGF-2 mRNA in the prefrontal cortex and the striatum, and a down-regulation of the expression of FGF-2 mRNA in the hypothalamus of the rat brain. Acute treatment with E-5842 (one single administration and animals killed 6 h later) up-regulated FGF-2 expression in the prefrontal cortex, the striatum, the hypothalamus and the hippocampus in a dose-dependent manner. The acute up-regulation was transient and disappeared 24 h after E-5842 administration. The induction of FGF-2 in the striatum after repeated administration has been described for clozapine, but our data concerning regulation in the prefrontal cortex suggest that this effect is unique to E-5852 among other antipsychotics. Given the neuroprotective activity of FGF-2, the data presented here might be relevant to the deficit in cognition and other symptoms that appear in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:58:41