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Titolo:
Neurochemical and electrophysiological evidence that 5-HT4 receptors exerta state-dependent facilitatory control in vivo on nigrostriatal, but not mesoaccumbal, dopaminergic function
Autore:
Lucas, G; Di Matteo, V; De Deurwaerdere, P; Porras, G; Martin-Ruiz, R; Artigas, F; Esposito, E; Spampinato, U;
Indirizzi:
Univ Bordeaux 2, Lab Neuropsychobiol Desadaptat, CNRS, UMR 5541, F-33077 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33077 R 5541, F-33077 Bordeaux, France Consorzio Mario Negri Sud, Ist Ric Farmacol Mario Negri, Chieti, Italy Consorzio Mario Negri Sud Chieti Italy macol Mario Negri, Chieti, Italy CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Barcelona 08036, Spain CSIC Barcelona Spain 08036 vest Biomed Barcelona, Barcelona 08036, Spain
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 889 - 898
SICI:
0953-816X(200103)13:5<889:NAEET5>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALOPERIDOL-INDUCED CATALEPSY; DORSAL RAPHE NUCLEUS; IN-VIVO; SEROTONIN 5-HT4; RAT-BRAIN; PHARMACOLOGICAL CHARACTERIZATION; BINDING-SITES; QUANTITATIVE AUTORADIOGRAPHY; ELECTRICAL-STIMULATION; ANTIPSYCHOTIC-DRUGS;
Keywords:
dopamine release; dopaminergic neuron firing rate; GR 125487; microdialysis; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Spampinato, U Univ Bordeaux 2, Lab Neuropsychobiol Desadaptat, CNRS, UMR 5541, BP 31,146Rue Leo Saignat, F-33077 Bordeaux, France Univ Bordeaux 2 BP 31,146 Rue Leo Saignat Bordeaux France F-33077
Citazione:
G. Lucas et al., "Neurochemical and electrophysiological evidence that 5-HT4 receptors exerta state-dependent facilitatory control in vivo on nigrostriatal, but not mesoaccumbal, dopaminergic function", EUR J NEURO, 13(5), 2001, pp. 889-898

Abstract

In this study we investigated, using in vivo microdialysis and single unitrecordings, the role of serotonin(4) (5-HT4) receptors in the control of nigrostriatal and mesoaccumbal dopaminergic (DA) pathway activity. In freelymoving rats, the 5-HT4 antagonist GR 125487 (1 mg/kg, i.p.), without effect on its own, significantly reduced the enhancement of striatal DA outflow induced by 0.01 (-35%) and 0.1 (-66%), but not 1 mg/kg, s.c. haloperidol (HAL). Intrastriatal infusion of GR 125487 (1 mum) had no influence on basal DA outflow, but attenuated (-49%) the effect of 0.01 mg/kg HAL. Systemic administration of GR 125487 modified neither basal nor 0.01 mg/kg HAL-stimulated accumbal DA outflow. In halothane-anaesthetized rats, 1 or 10 mg/kg GR 125487, without effect by itself, failed to modify the changes in accumbal and striatal DA outflow elicited by electrical stimulation (300 muA, 1 ms, 20 Hz, 15 min) of the dorsal raphe nucleus. Finally, GR 125487 (444 mug/kg,i.v.), whilst not affecting basal firing of DA neurons within either the substantia nigra or the ventral tegmental area, reduced HAL-stimulated (1-300 mug/kg, i.v.) impulse flow of nigrostriatal DA neurons only. These results indicate that 5-HT4 receptors exert a facilitatory control on both striatal DA release and nigral DA neuron impulse flow only when nigrostriatal DA transmission is under activated conditions. Furthermore, they indicate thatthe striatum constitutes a major site for the expression of the control exerted by 5-HT4 receptors on DA release. In contrast, 5-HT4 receptors have no influence on mesoaccumbal DA activity in either basal or activated conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:12:31