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Titolo:
Social isolation after a single defeat reduces striatal dopamine transporter binding in rats
Autore:
Isovich, E; Engelmann, M; Landgraf, R; Fuchs, E;
Indirizzi:
German Primate Ctr, Div Neurobiol, Gottingen, Germany German Primate Ctr Gottingen Germany Div Neurobiol, Gottingen, Germany Otto von Guericke Univ, Inst Med Neurobiol, Magdeburg, Germany Otto von Guericke Univ Magdeburg Germany Neurobiol, Magdeburg, Germany Max Planck Inst Psychiat, Inst Clin, Dept Neuroendocrinol, D-8000 Munich, Germany Max Planck Inst Psychiat Munich Germany D-8000 l, D-8000 Munich, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 13, anno: 2001,
pagine: 1254 - 1256
SICI:
0953-816X(200103)13:6<1254:SIAASD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOSOCIAL STRESS; DEPRESSION; COCAINE; NEUROBIOLOGY; AGGRESSION; BEHAVIOR; SUPPORT; SITES; BRAIN;
Keywords:
depression; dopamine; isolation; social stress; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, E German Primate Ctr, Div Neurobiol, Gottingen, Germany German Primate Ctr Gottingen Germany obiol, Gottingen, Germany
Citazione:
E. Isovich et al., "Social isolation after a single defeat reduces striatal dopamine transporter binding in rats", EUR J NEURO, 13(6), 2001, pp. 1254-1256

Abstract

A single social defeat in male rats has long lasting physiological and behavioural consequences, which are similar to those seen in depressive patients. In addition, the housing conditions after social defeat appear to be crucial for the development of depression-like symptoms. Because the dopaminergic system is thought to be altered in depressive illness, we investigatedthe impact of individual and group housing on the temporal development of changes of dopamine transporter (DAT) binding in male rats after a single social defeat. The number of striatal DAT binding sites was reduced in animals that remained isolated after being defeated. The isolation length after social defeat amplified this effect, indicating a temporal development of the changes on the striatal DAT. In animals which returned to the familiar group after social defeat the density of striatal DAT binding sites was not affected. We conclude that social isolation after a single defeat reduces the number of DAT binding sites. In contrast, a familiar environment after asingle social defeat appears to prevent the stress-induced alterations on the dopaminergic system. This finding suggests that housing conditions are critical when investigating the central nervous effects of social defeat inmale rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:30:02