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Titolo:
Acute inhibitory effect of alcohol on fibrinolysis
Autore:
van de Wiel, A; van Golde, PM; Kraaijenhagen, RJ; von dem Borne, PAK; Bouma, BN; Hart, HC;
Indirizzi:
Eemland Hosp, Dept Internal Med, NL-3800 BM Amersfoort, Netherlands Eemland Hosp Amersfoort Netherlands NL-3800 BM M Amersfoort, Netherlands Eemland Hosp, Dept Clin Chem, NL-3800 BM Amersfoort, Netherlands Eemland Hosp Amersfoort Netherlands NL-3800 BM M Amersfoort, Netherlands Univ Utrecht Hosp, Dept Haematol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands NL-3508 GA GA Utrecht, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 2, volume: 31, anno: 2001,
pagine: 164 - 170
SICI:
0014-2972(200102)31:2<164:AIEOAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE; PLASMINOGEN-ACTIVATOR INHIBITOR; ACUTE MYOCARDIAL-INFARCTION; CIRCADIAN VARIATION; RED WINE; INSULIN SENSITIVITY; RISK FACTOR; CONSUMPTION; PLASMA;
Keywords:
alcohol; binge drinking; coronary heart disease; fibrinolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: van de Wiel, A Eemland Hosp, Dept Internal Med, POB 1502, NL-3800 BM Amersfoort, Netherlands Eemland Hosp POB 1502 Amersfoort Netherlands NL-3800 BMds
Citazione:
A. van de Wiel et al., "Acute inhibitory effect of alcohol on fibrinolysis", EUR J CL IN, 31(2), 2001, pp. 164-170

Abstract

Background In contrast to a reduced risk of coronary heart disease (CHD) with light to moderate alcohol consumption, heavy alcohol intake and binge drinking are associated with increased cardiovascular mortality. Alcohol hasan acute and profound effect on fibrinolysis that may be relevant to the pathogenesis of CHD. Materials and methods The short-term effects of a low (two glasses, 250 mL, 20 g ethanol) and a high (six glasses, 750 mL, 60 g ethanol) intake of red wine were studied in male volunteers and compared to the intake of mineral water. To find a threshold for inhibition of fibrinolysis and to study a binge effect, a second experiment was performed comparing the intake of four (500 mL, 40 g ethanol) and eight (1000 mL, 80 g ethanol) glasses of red wine with mineral water. Plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (t-PA), plasmin-antiplasmin (PAP) complexes and clot lysis time were measured. Results In contrast to the circadian rhythm with an enhanced fibrinolysis in the evening that was found in the mineral water group, an intake above four glasses of wine inhibited fibrinolysis significantly. After the intake of two glasses no significant disturbance of the circadian rhythm was observed. Five hours after the consumption of six glasses of wine, a dramatic increase occurred of PAI-1 antigen (77 +/- 42 mug L-1 vs. -5 +/- 10 mug L-1 in the mineral water controls; P< 0.001) and PAI-1 activity (27 +/- 15 U mL(-1) vs. -2 +/- 3 U mL(-1) in mineral water controls; P < 0.001). Despite a rise in t-PA antigen, t-PA activity dropped (- 0.5 +/- 0.2 U mL(-1) vs. - 0.1 +/- 0.2 in controls; P < 0.001) as did PAP complexes (- 103 +/- 55 <mu>gL-1 vs. - 26 +/- 57 mug L-1 in controls; P < 0.01). After the consumption of eight glasses of wine, the clot lysis assay indicated continued inhibition of fibrinolysis the following morning. Conclusions Drinking a large amount of alcohol in the evening results in an acute inhibition of fibrinolysis, persisting the following morning. This may predispose to accelerated atherosclerosis and set the stage for thrombotic coronary events, explaining the higher cardiovascular mortality risk inbinge drinkers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:17:28