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Titolo:
Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease
Autore:
Muller, B; Tsakiris, DA; Roth, CB; Guglielmetti, M; Staub, JJ; Marbet, GA;
Indirizzi:
Univ Basel Hosp, Hemostasis Lab, Dept Cent Lab, CH-4031 Basel, SwitzerlandUniv Basel Hosp Basel Switzerland CH-4031 ab, CH-4031 Basel, Switzerland Univ Basel Hosp, Dept Med, Div Endocrinol Diabetol & Metab, CH-4031 Basel,Switzerland Univ Basel Hosp Basel Switzerland CH-4031 tab, CH-4031 Basel,Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 2, volume: 31, anno: 2001,
pagine: 131 - 137
SICI:
0014-2972(200102)31:2<131:HPIHAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; FACTOR-VII; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SUBCLINICAL HYPOTHYROIDISM; POSTMENOPAUSAL WOMEN; ORAL-CONTRACEPTIVES; THYROID-HORMONES; FIBRINOGEN; ATHEROSCLEROSIS;
Keywords:
Factor VII; hypercoagulable state; subclinical hypothyroidism; von Willebrand factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Tsakiris, DA Univ Basel Hosp, Hemostasis Lab, Dept Cent Lab, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 asel, Switzerland
Citazione:
B. Muller et al., "Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease", EUR J CL IN, 31(2), 2001, pp. 131-137

Abstract

Background The influence of thyroid failure on haemostasis is controversial, both hypocoagulable and hypercoagulable states have been reported. Sinceboth subclinical and overt hypothyroidism have been associated with atherosclerosis, a hypercoagulable state in addition might represent a risk factor for thromboembolic disease. Design We investigated various haemostatic variables in 42 women with subclinical hypothyroidism and compared them to 66 euthyroid controls. Prothrombin time, activated partial thromboplastin time, fibrinogen, factor VII activity (FVII:C), factor VII antigen (FVII:Ag), factor VIII activity, von Willebrand factor (vWF), antithrombin III, heparin cofactor II, protein C, protein S, plasminogen, antiplasmin, plasminogen activator inhibitor and tissue plasminogen activator, as well as common lipid variables, were measured. Results Factor VII:C (P < 0.02) and the ratio FVII:C/FVII:Ag (P < 0.01) were significantly increased in subclinical hypothyroid patients compared to the control group. Both parameters remained higher in hypothyroid patients after exclusion of 18 women on oestrogen replacement therapy. No differences were found between the groups with respect to vWF or the other haemostatic and lipid variables tested. Conclusion Patients with subclinical hypothyroidism had significantly higher levels of FVII:C. The greater increase in FVII:C compared to that of FVII:Ag, as shown by the increase in their ratio, might reflect the presence of activated FVIIa. This might mean a hypercoagulable state, which could contribute to the increased prevalence of coronary heart disease reported in such patients. A hypercoagulable state might be another argument in favour of thyroxine replacement treatment in subclinical hypothyroidism, especiallyin patients with additional risk factors for vascular disease.

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Documento generato il 30/09/20 alle ore 05:54:41