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Titolo:
Effects of a novel synthetic retinoid on malignant glioma in vitro: inhibition of cell proliferation, induction of apoptosis and differentiation
Autore:
Costa, SL; Paillaud, E; Fages, C; Rochette-Egly, C; Plassat, JL; Jouault, H; Perzelova, A; Tardy, M;
Indirizzi:
Fac Med, INSERM U421, F-94010 Creteil, France Fac Med Creteil France F-94010 Med, INSERM U421, F-94010 Creteil, France Inst Genet & Biol Mol & Cellulaire, Illkirch, France Inst Genet & Biol Mol& Cellulaire Illkirch France re, Illkirch, France Hop Henri Mondor, Serv Hematol Biol, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 ol Biol, F-94010 Creteil, France Comenius Univ, Sch Med, Bratislava, Slovakia Comenius Univ Bratislava Slovakia s Univ, Sch Med, Bratislava, Slovakia
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 4, volume: 37, anno: 2001,
pagine: 520 - 530
SICI:
0959-8049(200103)37:4<520:EOANSR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; RECEPTOR-SELECTIVE RETINOIDS; LUNG-CARCINOMA CELLS; GLUTAMINE-SYNTHETASE; CANCER CELLS; IN-VIVO; GROWTH; ACTIVATION; DEATH; LINES;
Keywords:
retinoids; CD437; glioma; apoptosis; differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tardy, M Fac Med, INSERM U421, 8 Rue Gen Sarrail, F-94010 Creteil, France Fac Med 8 Rue Gen Sarrail Creteil France F-94010 Creteil, France
Citazione:
S.L. Costa et al., "Effects of a novel synthetic retinoid on malignant glioma in vitro: inhibition of cell proliferation, induction of apoptosis and differentiation", EUR J CANC, 37(4), 2001, pp. 520-530

Abstract

Among six synthetic retinoids tested, the retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) was highly efficient in inducing growth inhibition of 8MG-BA and GL-15 human glioblastoma cell lines, with growth arrest at the S phase of the cell cycle. CD 437 also inducedapoptosis in these cells, with 8MG-BA being the most sensitive. In these cells, induction of apoptosis by CD437 has been related to the downregulation of Bcl-2 expression and to CPP32 activation, but not to p53 expression. The remaining non-apoptotic cells presented a morphological pattern of astroglial differentiation with overexpression of glial fibrillary acidic protein (GFAP) and glutamine synthetase (GS). The mechanism of action of CD437, originally developed as a RAR gamma agonist, is not yet elucidated. However,our results suggest that it acts through an increase of the expression of retinoid-inducible genes, such as RAR beta2 and/or RAR alpha2. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:29:16