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Titolo:
Effects of mutations in mitochondrial cytochrome b in yeast and man - Deficiency, compensation and disease
Autore:
Fisher, N; Meunier, B;
Indirizzi:
Univ Coll London, Dept Biol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT Biol, London WC1E 6BT, England
Titolo Testata:
EUROPEAN JOURNAL OF BIOCHEMISTRY
fascicolo: 5, volume: 268, anno: 2001,
pagine: 1155 - 1162
SICI:
0014-2956(200103)268:5<1155:EOMIMC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX-III DEFICIENCY; CATALYTIC CENTER-N; SACCHAROMYCES-CEREVISIAE; ELECTRON-TRANSFER; BC(1) COMPLEX; C REDUCTASE; EXERCISE INTOLERANCE; GENE; UBIQUINOL; MUTANTS;
Keywords:
bc(1) complex; human disease; mutations; reversions; yeast;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Meunier, B Univ Coll London, Dept Biol, Mortimer St, London WC1E 6BT, England Univ Coll London Mortimer St London England WC1E 6BT , England
Citazione:
N. Fisher e B. Meunier, "Effects of mutations in mitochondrial cytochrome b in yeast and man - Deficiency, compensation and disease", EUR J BIOCH, 268(5), 2001, pp. 1155-1162

Abstract

The mitochondrial cytochrome bc(1) complex is a key protonmotive componentof eukaryotic respiratory chains. The mitochondrially encoded cytochrome bforms, with cytochrome c(1) and the iron-sulfur protein, the catalytic core of this multimeric enzyme. Mutations of cytochrome b have been reported in association with human diseases. In the highly homologous yeast cytochrome b, several mutations that impair the respiratory function, and reversionsthat correct the defect, have been described. In this paper, we re-examinethe mutations in the light of the atomic structure of the complex, and discuss the possible effect, at enzyme level, of the human cytochrome b mutations and the correcting effect of the reversions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:21:12