Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inducible nitric oxide synthase attenuates chronic colitis in HLA-B27/human beta 2-microglobulin transgenic rats
Autore:
Blanchard, HS; Dernis-Labous, E; Lamarque, D; van Nhieu, JT; Szepes, Z; Flejou, JF; Wollman, E; Whittle, BJR; Breban, M;
Indirizzi:
Univ Paris 05, Hop Cochin, AP HP,INSERM U477, Inst Rhumatol, F-75014 Paris, France Univ Paris 05 Paris France F-75014 Inst Rhumatol, F-75014 Paris, France Hop Henri Mondor, AP HP, INSERM U99, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 ERM U99, F-94010 Creteil, France Hop Henri Mondor, AP HP, Dept Gastroenterol, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 enterol, F-94010 Creteil, France Hop Henri Mondor, AP HP, Dept Pathol, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 Pathol, F-94010 Creteil, France Hop Beaujon, Dept Pathol, AP HP, F-92110 Clichy, France Hop Beaujon Clichy France F-92110 Pathol, AP HP, F-92110 Clichy, France St Bartholomews Med Coll, William Harvey Res Inst, London, England St Bartholomews Med Coll London England arvey Res Inst, London, England Univ Paris 05, AP HP, Hop Cochin, Dept Rheumatol, F-75014 Paris, France Univ Paris 05 Paris France F-75014 Dept Rheumatol, F-75014 Paris, France
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 1, volume: 12, anno: 2001,
pagine: 111 - 118
SICI:
1148-5493(200103)12:1<111:INOSAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; NECROSIS-FACTOR-ALPHA; INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; EPITHELIAL-CELLS; CROHNS-DISEASE; EXPRESSION; ENDOTOXIN; MECHANISMS; CYTOKINES;
Keywords:
rodent; inflammation; nitric oxide; cylokines; in vivo animal models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Breban, M Univ Paris 05, Hop Cochin, AP HP,INSERM U477, Inst Rhumatol, 27 Rue Faubourg St Jacques, F-75014 Paris, France Univ Paris 05 27 Rue Faubourg St Jacques Paris France F-75014 e
Citazione:
H.S. Blanchard et al., "Inducible nitric oxide synthase attenuates chronic colitis in HLA-B27/human beta 2-microglobulin transgenic rats", EUR CYTOKIN, 12(1), 2001, pp. 111-118

Abstract

Rats transgenic for HLA-B27/human beta (2)-microglobulin develop a spontaneous multisystem inflammatory disorder that closely mimicks human spondyloarthropathies Prominent features of this disorder are gut inflammation that predominates in the colon, and arthritis. Several mediators such as IFN-gamma, IL-1 beta, TNF-alpha, and inducible nitric oxide synthase (iNOS) have been found increased in the inflamed colonic mucosa, In the colon of HLA-B27transgenic rats, iNOS is predominantly expressed by epithelial cells, and iNOS transcripts are detected in the hip cartilage of those rats, but not in nontransgenic littermates. The role of iNOS in this disorder was evaluated by administering the corticosteroid dexamethasone, or the NOS inhibitor L-N-6-(1-iminoethyl)lysine (L-NIL) to HLA-B27 transgenic rats with established disease. Treatment with dexamethasone attenuated some aspects of gut inflammation, although it had no effect on iNOS expression. In contrast, treatment with L-NIL effectively inhibited iNOS activity, and resulted in an increase in colitis. Cytokine transcripts in the colon were modified by these treatments: IFN-gamma and IL-1 beta were decreased after dexamethasone treatment, whereas administration of L-NIL resulted in decreased IFN-gamma, andTNF-alpha, A trend towards increased IL-1 beta expression was observed which could have contributed to the L-NIL pro-inflammatory effect. These results suggest that iNOS exerts a protective effect on colitis, in the inflammatory disorder of HLA-B27 transgenic rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:18:59