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Titolo:
Transforming growth factor-beta1 and interferon-alpha in the AIDS dementiacomplex (ADC): possible relationship with cerebral viral load?
Autore:
Perrella, O; Carrieri, PB; Perrella, A; Sbreglia, C; Gorga, F; Guarnaccia, D; Tarantino, G;
Indirizzi:
Hosp D Cotugno, Dept Immunol & Infect Dis, Naples, Italy Hosp D Cotugno Naples Italy o, Dept Immunol & Infect Dis, Naples, Italy Univ Naples Federico II, Dept Neurol, Naples, Italy Univ Naples Federico II Naples Italy ico II, Dept Neurol, Naples, Italy Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, Naples, Italy UnivNaples Federico II Naples Italy ept Clin & Expt Med, Naples, Italy Univ Naples 2, Inst Microbiol, Naples, Italy Univ Naples 2 Naples ItalyUniv Naples 2, Inst Microbiol, Naples, Italy
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 1, volume: 12, anno: 2001,
pagine: 51 - 55
SICI:
1148-5493(200103)12:1<51:TGFAII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CENTRAL-NERVOUS-SYSTEM; HUMAN LYMPHOCYTES-T; FACTOR-BETA; CEREBROSPINAL-FLUID; MULTIPLE-SCLEROSIS; NEUROLOGICAL DISORDERS; POTENTIAL ROLE; VIRUS; CYTOKINES;
Keywords:
transforming growth factor-beta1; HIV-RNA; AIDS-dementia complex; interferon-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Perrella, O Via EA Mario 35, I-80128 Naples, Italy Via EA Mario 35 Naples Italy I-80128 , I-80128 Naples, Italy
Citazione:
O. Perrella et al., "Transforming growth factor-beta1 and interferon-alpha in the AIDS dementiacomplex (ADC): possible relationship with cerebral viral load?", EUR CYTOKIN, 12(1), 2001, pp. 51-55

Abstract

Mechanisms involved in the pathogenesis of the AIDS-dementia complex are still unclear. The dichotomy between a small number of HIV-infected cells inthe brain and their marked dysfunction could be related to a cellular amplification and/or activation of cerebral viral load by several cytokines, This link between cytokines and viral load could play a role in the generation of the clinical dementia syndrome. We have studied cerebral levels of transforming growth factor-beta1 and interferon-alpha, both in the mild and severe AIDS-dementia complex and also compared these cytokines with HIV RNA load in patients with different degrees of dementia, Our data indicate that production of different cytokines characterized the expression of clinical dementia, In the mild AIDS-dementia complex, there was a significant inverse correlation between interferon-alpha and transforming factor-beta1 (r = -0.743; p < 0.001), and HIV-RNA was present in inverse proportion to transforming growth beta1 (r = -0.751; p < 0.001), In patients with severe AIDS-dementia, transforming factor-beta1 was undetectable, while interferon-alpha level were higher than in mild AIDS dementia and correlated, positively to cerebral HIV-RNA, No significant difference was evident between these cytokines in the serum of ADC patients and in the control samples, Our study suggests that a relationship is possible between productive HIV infection in the cerebral nervous system and a heterogenous and different expression of the immune response via a complex interaction of cytokines with a differential modulation of the dementia phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:36:58