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Titolo:
Role of cytokines in the modulation of nitric oxide production by cyclic AMP
Autore:
Zidek, Z;
Indirizzi:
Acad Sci Czech Republ, Inst Pharmacol, Lab Mol Immunopharmacol, Prague 14220, Czech Republic Acad Sci Czech Republ Prague Czech Republic 14220 14220, Czech Republic
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 1, volume: 12, anno: 2001,
pagine: 22 - 32
SICI:
1148-5493(200103)12:1<22:ROCITM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE CELLS; NF-KAPPA-B; MURINE PERITONEAL-MACROPHAGES; PHOSPHODIESTERASE INHIBITOR ROLIPRAM; VASOACTIVE-INTESTINAL-PEPTIDE; ARACHIDONIC-ACID RELEASE; SYNTHASE GENE-EXPRESSION; RENAL MESANGIAL CELLS; RAT KUPFFER CELLS;
Keywords:
cyclic AMP; prostaglandins; nitric oxide; interleukin-10; tumor necrosis factor-alpha; interferon-gamma;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
178
Recensione:
Indirizzi per estratti:
Indirizzo: Zidek, Z Acad Sci Czech Republ, Inst Pharmacol, Lab Mol Immunopharmacol, Videnska 1083, Prague 14220, Czech Republic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 14220
Citazione:
Z. Zidek, "Role of cytokines in the modulation of nitric oxide production by cyclic AMP", EUR CYTOKIN, 12(1), 2001, pp. 22-32

Abstract

Enhanced levels of cyclic AMP (cAMP), resulting from stimulation of adenylyl cyclase through activation of distinct pharmacological receptor systems,have a remarkable impact on the activity of the immune system, Among otherresponses, production of nitric oxide (NO) is also affected. The effects of cAMP range from stimulation to inhibition (or no effect) of immune-stimulated biosynthesis of NO, with a preponderance of stimulatory interference. cAMP has been shown to be a potent, dual modulator of cytokine expression. It dose-dependently suppresses secretion of major NO up-regulatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma),On the other hand, production of IL-10, which is known to regulate the inducible NO synthase (iNOS) activation in both a positive and negative direction, is inversely enhanced. It is suggested that the dual effects of cAMP on NO formation are likely to result from the differences in the concentration ratio of these cytokines, The value of this parameter depends on the type and concentration of cAMP-stable derivatives and cAMP-enhancing agents, such as prostaglandins, beta -adrenoceptor agonists, phosphodiesterase inhibitors, forskolin and cholera toxin, The cytokine ratio may be influenced bydynamically developing multiple down- and up-regulatory feedback circuits among cytokines, NO, and cAMP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:41:03