Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lipodystrophy syndrome in patients with HIV infection - Quality of life issues
Autore:
Martinez, E; Garcia-Viejo, MA; Blanch, J; Gatell, JM;
Indirizzi:
Hosp Clin Barcelona, Infect Dis Unit, Clin Inst Infect & Immunol, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 ol, E-08036 Barcelona, Spain Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 er, E-08036 Barcelona, Spain Hosp Clin Barcelona, Psychiat Unit, Clin Inst Psychol & Psychiat, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 at, E-08036 Barcelona, Spain
Titolo Testata:
DRUG SAFETY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 157 - 166
SICI:
0114-5916(2001)24:3<157:LSIPWH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; INHIBITOR-ASSOCIATED LIPODYSTROPHY; ACTIVE ANTIRETROVIRAL THERAPY; HAT-QOL INSTRUMENT; METABOLIC ABNORMALITIES; PROTEASE INHIBITORS; FAT REDISTRIBUTION; MITOCHONDRIAL TOXICITY; DIABETES-MELLITUS; HYPERTRIGLYCERIDEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, E Hosp Clin Barcelona, Infect Dis Unit, Clin Inst Infect & Immunol, C Villarroel 170, E-08036 Barcelona, Spain Hosp Clin Barcelona C Villarroel 170 Barcelona Spain E-08036
Citazione:
E. Martinez et al., "Lipodystrophy syndrome in patients with HIV infection - Quality of life issues", DRUG SAFETY, 24(3), 2001, pp. 157-166

Abstract

Current antiretroviral therapy has lead to longer survival in patients infected with HIV. but it is also associated with new and important problems. Body fat redistribution and metabolic abnormalities, the so-called lipodystrophy syndrome, are among the most prevalent and worrisome ones. While an increasing number of patients infected with HIV are becoming affected by this syndrome, the pathogenesis of this syndrome and how to prevent and treat the problem all remain largely unknown. Body fat changes stigmatise the bodies of patients infected with HIV giving them a similar look to that seen in patients some years ago when the wasting syndrome was more prevalent and HIV infection was ultimately fatal. Thepsychological impact of body fat changes may be severe enough to affect a patients' desire to continue with antiretroviral therapy. Metabolic abnormalities, probably with the exception of symptomatic diabetes mellitus and hypertriglyceridaemia-induced pancreatitis, do not have an immediate impact on the quality of the lives of patients with HIV. However, their potential long term cardiovascular and bone consequences may increase the morbidity and the mortality of patients infected with HIV through noninfectious diseases. The impact of lipodystrophy on patients infected with HIV is not readilycaptured with the classic instruments used to measure quality of life and hence it is necessary to modify them urgently. Though treating lipodystrophy seems fully justified, there is no proven treatment for this problem, although a number of treatments have been used with varying success. Despite the recognition that lipodystrophy may have important psychological repercussions, the best psychological approach for this problem is not known at present. Although lipodystrophy has its own peculiarities, existing knowledge about how to psychologically help other patients with deforming body changes might be of help for patients infected with HIV, or at least may act as astarting point.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:28:06