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Titolo:
Microalbuminuria in patients with Type 2 diabetes mellitus from general practice: course and predictive value
Autore:
de Grauw, WJC; van de Lisdonk, EH; van Gerwen, WHEM; Verstappen, M; van den Hoogen, HJM; Willems, JL; van Weel, C;
Indirizzi:
Univ Nijmegen, Dept Gen Practice & Social Med, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands Univ Nijmegen, Dept Epidemiol, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands ept Epidemiol, Nijmegen, Netherlands Univ Nijmegen, Univ Med Ctr, Dept Clin Chem, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands ept Clin Chem, Nijmegen, Netherlands
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 2, volume: 18, anno: 2001,
pagine: 139 - 143
SICI:
0742-3071(200102)18:2<139:MIPWT2>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; NATURAL-HISTORY; NEPHROPATHY; NIDDM; PROTEINURIA; MORTALITY; PROGRESSION; ALBUMINURIA; PREVENTION;
Keywords:
cardiovascular morbidity; general practice; microalbuminuria; mortality; Type 2 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: de Grauw, WJC Univ Nijmegen, Dept Gen Practice & Social Med, Postbus 9101,NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Postbus 9101 Nijmegen Netherlands NL-6500 HB
Citazione:
W.J.C. de Grauw et al., "Microalbuminuria in patients with Type 2 diabetes mellitus from general practice: course and predictive value", DIABET MED, 18(2), 2001, pp. 139-143

Abstract

Aims To assess the course of microalbuminuria in patients with Type 2 diabetes mellitus in general practice and the predictive value of urinary albumin concentration on all-cause mortality, cardiovascular mortality and cardiovascular morbidity. Methods Cohort study in Type 2 diabetic patients tested for microalbuminuria in 1992, and re-tested in 1998. During follow-up all cardiovascular morbidity and mortality were recorded. Results Of the original sample of 317 patients, 163 patients were re-tested. The mean change in urinary albumin concentration was +16.2 mg/l (range -122.0 to +602 mg/l). Seventy-five per cent of the patients without microalbuminuria in 1992 still had no microalbuminuria in 1998 and 40% of those with microalbuminuria in 1992 reverted to normoalbuminuria in 1998. Cox survival analysis, stratified for age, showed that microalbuminuria at baseline resulted in a risk ratio of all-cause mortality of 1.4 (95% confidence interval 0.8-2.7), of cardiovascular mortality of 1.2 (0.5-2.8) and of new cardiovascular events (including cardiovascular mortality) of 1.4 (0.8-2.3). Conclusions In the majority of patients the change of urinary albumin excretion was small, but the range was wide. A weak non-significant relationship between microalbuminuria and all-cause mortality and cardiovascular morbidity was observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:23:33