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Titolo:
The 2nd to 4th digit ratio and autism
Autore:
Manning, JT; Baron-Cohen, S; Wheelwright, S; Sanders, G;
Indirizzi:
Univ Liverpool, Sch Biol Sci, Populat & Evolutionary Biol Res Grp, Liverpool L69 3BX, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3BX , Merseyside, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England Univ Cambridge, Dept Psychiat, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB iat, Cambridge CB2 3EB, England London Guildhall Univ, Dept Psychol, London, England London Guildhall Univ London England niv, Dept Psychol, London, England
Titolo Testata:
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
fascicolo: 3, volume: 43, anno: 2001,
pagine: 160 - 164
SICI:
0012-1622(200103)43:3<160:T2T4DR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINOR PHYSICAL ANOMALIES; CEREBRAL LATERALIZATION; CHILDREN; PSYCHOSIS; ASYMMETRY; DISEASE; LENGTH; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Manning, JT Univ Liverpool, Sch Biol Sci, Populat & Evolutionary Biol Res Grp, Nicholson Bldg, Liverpool L69 3BX, Merseyside, England Univ Liverpool Nicholson Bldg Liverpool Merseyside England L69 3BX
Citazione:
J.T. Manning et al., "The 2nd to 4th digit ratio and autism", DEVELOP MED, 43(3), 2001, pp. 160-164

Abstract

It has been suggested that autism may arise as the result of exposure to high concentrations of prenatal testosterone. There is evidence that the ratio of the lengths of the and and 4th digit (2D:4D) may be negatively correlated with prenatal testosterone. We measured 2D:4D in 95 families recruitedvia the National Autistic Society, UK. The sample comprised a total 72 children with autism (62 males, 10 females; age range 2 to 14 years), including 23 children (20 males, three females) with Asperger syndrome(AS), 34 siblings, 88 fathers, 88 mothers and sex- and age-matched control participants. We found that the 2D:4D ratios of children with autism, their siblings, fathers and mothers were lower than population normative values. Children with AS, who share the social and communicative symptoms of autism but have normal or even high IQ, had higher 2D:4D ratios than children with autism butlower ratios than population normative values. There were positive associations between 2D:4D ratios of children with autism and the ratios of their relatives. Children with autism had lower than expected 2D:4D ratios and children with AS higher ratios than expected in relation to their fathers' 2D:4D ratio. It was concluded that 2D:4D ratio may be a possible marker for autism which could implicate prenatal testosterone in its aetiology.

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Documento generato il 07/04/20 alle ore 21:50:43