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Titolo:
Loss-of-function mutations reveal that the Drosophila nautilus gene is notessential for embryonic myogenesis or viability
Autore:
Balagopalan, L; Keller, CA; Abmayr, SM;
Indirizzi:
Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA PennState Univ University Pk PA USA 16802 l, University Pk, PA 16802 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 231, anno: 2001,
pagine: 374 - 382
SICI:
0012-1606(20010315)231:2<374:LMRTTD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR; MYOD FAMILY; MUSCLE DIFFERENTIATION; MYOBLAST CITY; CELL FATE; EMBRYOGENESIS; EXPRESSION; MEMBER; TWIST; MELANOGASTER;
Keywords:
drosophila; nautilus; myogenesis; differentiation; mutations; embryogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Abmayr, SM Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 ty Pk, PA 16802 USA
Citazione:
L. Balagopalan et al., "Loss-of-function mutations reveal that the Drosophila nautilus gene is notessential for embryonic myogenesis or viability", DEVELOP BIO, 231(2), 2001, pp. 374-382

Abstract

nautilus (nau), the single Drosophila member of the bHLH-containing myogenic regulatory family of genes, is expressed in a subset of muscle precursors and differentiated fibers. It is capable of inducing muscle-specific transcription as well as myogenic transformation, and plays a role in the differentiation of a subset of muscle precursors into mature muscle fibers. In previous studies, the nau zygotic loss-of-function phenotype was determined using genetic deficiencies in which the gene is deleted. We note that this genetic loss-of-function phenotype differs from the loss-of-function phenotype determined using RNA interference (L. Misquitta and B. M. Paterson, 1999, Proc. Natl. Acad. Sci. USA 96, 1451-1456). The present study re-examinesthis loss of-function phenotype using EMS-induced mutations that specifically alter the nan gene, and extends the genetic analysis to include the loss of both maternal and zygotic nau function. In brief, embryos lacking nau both maternally and zygotically are missing a distinct subset of muscle fibers, consistent with its apparent expression in a subset of muscle fibers. The muscle loss is tolerated, however, such that the loss of nau both maternally and zygotically does not result in lethality at any stage of development. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:04:14