Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DELETIONS OF THE N-TERMINAL REGIONS OF THE HUMAN MELANOCORTIN RECEPTORS
Autore:
SCHIOTH HB; PETERSSON S; MUCENIECE R; SZARDENINGS M; WIKBERG JES;
Indirizzi:
UPPSALA UNIV,CTR BIOMED,DEPT PHARMACEUT PHARMACOL,BOX 591 S-75124 UPPSALA SWEDEN LATVIAN ACAD SCI,INST ORGAN SYNTH,PHARMACOL LAB LV-226006 RIGA LATVIA
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 410, anno: 1997,
pagine: 223 - 228
SICI:
0014-5793(1997)410:2-3<223:DOTNRO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; EXPRESSION; BINDING; LOCALIZATION; MSH;
Keywords:
MELANOCORTIN (MC) RECEPTOR; MSH; LIGAND BINDING; N TERMINUS; TRUNCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H.B. Schioth et al., "DELETIONS OF THE N-TERMINAL REGIONS OF THE HUMAN MELANOCORTIN RECEPTORS", FEBS letters, 410(2-3), 1997, pp. 223-228

Abstract

The non-homologous N-terminal regions of four human melanocortin (MC)receptors were truncated in order to investigate their putative participation in ligand binding, Eleven constructs were made, where different numbers of residues from the N terminus were deleted, These constructs were used for transient expression experiments in COS cells and analysed by ligand binding. The results show that 27, 25, 28, and 20 amino acids could be deleted from the N terminus of the human MC1, MC3, MC4 and MC5 receptors, respectively, including all potential N-terminalglycosylation sites in the MC1 and the MC4 receptors, without affecting ligand binding or expression levels, The results indicate that the N-terminal regions of the human MC1, MC3, MC4 and MC5 receptors, do not play an important role for the ligand binding properties of these receptors. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:36:07