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Titolo:
Urinary cytokines for assessing inflammation in HIV-associated wasting
Autore:
Rivera, S; Sattler, FR; Boyd, H; Auffenberg, T; Nakao, S; Moldawer, LL;
Indirizzi:
Univ So Calif, Sch Med, Dept Med, Div Infect Dis, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 ect Dis, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Gen Clin Res Ctr, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Res Ctr, Los Angeles, CA 90033 USA Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32605 USA Univ FloridaGainesville FL USA 32605 ept Surg, Gainesville, FL 32605 USA
Titolo Testata:
CYTOKINE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 305 - 313
SICI:
1043-4666(20010307)13:5<305:UCFAII>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; IMMUNODEFICIENCY-VIRUS INFECTION; RESTING ENERGY-EXPENDITURE; ACUTE-PHASE RESPONSE; SOLUBLE RECEPTORS; WEIGHT-LOSS; FACTOR-ALPHA; TYPE-1 INFECTION; AIDS;
Keywords:
HIV wasting syndrome; interleukin 6; interleukin 1; receptors; tumor necrosis factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sattler, FR Univ So Calif, Los Angeles Cty Med Ctr, Rand Schrader clin, Room 351,1300 N Mission Rd, Los Angeles, CA 90033 USA Univ So Calif Room 351,1300 N Mission Rd Los Angeles CA USA 90033
Citazione:
S. Rivera et al., "Urinary cytokines for assessing inflammation in HIV-associated wasting", CYTOKINE, 13(5), 2001, pp. 305-313

Abstract

The relationship between cytokines and HIV-related weight loss has not been well established. Unlike most cytokines that are secreted in a paracrine manner, IL-6, sTNFR-II, acid IL-1ra are readily detected in the systemic circulation and serve as markers of the inflammatory response. Twenty-four-hour urine concentrations of these proteins are believed to provide an integrative assessment of their systemic levels over the preceding hours. We sought to determine whether spot measurements of IL-6, sTNFR-II, and IL-1ra could be related to subsequent 24h concentrations and prior weight loss. Eighteen subjects with severe wasting (average BMI = 18 +/- 3 kg/m(2) with 19 +/- 13 kg of weight loss) and six HIV-negative healthy subjects were tested. Compared to values in controls, 24-h urinary concentrations of the three proteins adjusted for creatinine excreted were elevated in 44%, 89%, and 72% of patients, respectively. Twenty-four-hour concentrations were highly correlated with the spot concentrations (r = 0.80, 0.87, 6.84, respectively, P<0.001), IL-1ra concentrations (24 h and spot) were correlated with weight loss in the previous 6 months, lifetime rate of weight loss and the 6 month rate of weight loss (spot: r = 0.66, 0.73, 0.68, respectively, P <less thanor equal to> 0.001). These data suggest that spot urinary collections can be used to estimate 24 h excretion rates. This strategy may be useful in assessing the inflammatory response in HIV-associated wasting. (C) 2001 Academic Press.

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Documento generato il 29/09/20 alle ore 22:46:32