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Titolo:
Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure
Autore:
Naeije, R; Brimioulle, S;
Indirizzi:
Free Univ Brussels, Dept Physiol, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 iol, B-1070 Brussels, Belgium Free Univ Brussels, Dept Intens Care, Erasme Hosp, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 osp, B-1070 Brussels, Belgium
Titolo Testata:
CRITICAL CARE
fascicolo: 2, volume: 5, anno: 2001,
pagine: 67 - 71
SICI:
1466-609X(2001)5:2<67:PIMIOH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED NITRIC-OXIDE; DISTRESS SYNDROME; GAS-EXCHANGE; INTACT DOGS; CIRCULATION; RESISTANCE; ISOFLURANE; ALMITRINE; CHANNELS; LUNGS;
Keywords:
acute respiratory failure; feedback; hypoxia; hypoxic pulmonary vasoconstriction; vascular smooth muscle cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Naeije, R Free Univ Brussels, Dept Physiol, CP 604,Erasme Campus,808 Lennik Rd, B-1070 Brussels, Belgium Free Univ Brussels CP 604,Erasme Campus,808 Lennik Rd Brussels Belgium B-1070
Citazione:
R. Naeije e S. Brimioulle, "Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure", CRIT CARE, 5(2), 2001, pp. 67-71

Abstract

Hypoxic pulmonary vasoconstriction continues to attract interest more thanhalf a century after its original report because of persistent mystery about its biochemical mechanism and its exact physiological function. Recent work suggests an important role for pulmonary arteriolar smooth muscle cell oxygen-sensitive voltage-dependent potassium channels. Inhibition of these channels by decreased PO, inhibits outward potassium current, causing membrane depolarization, and calcium entry through voltage-dependent calcium channels. Endothelium-derived vasoconstricting and vasodilating mediators modulate this intrinsic smooth muscle cell reactivity to hypoxia. However, refined modeling of hypoxic pulmonary vasoconstriction operating as a feedback mechanism in inhomogeneous lungs, using more realistic stimulus-response curves and confronted with direct measurements of regional blood flow distribution, shows a more effective than previously assessed ability of this remarkable intrapulmonary reflex to improve gas exchange and arterial oxygenation. Further studies could show clinical benefit of pharmacological manipulation of hypoxic pulmonary vasoconstriction, in circumstances of life-threatening hypoxemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:41:44