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Titolo:
Role of cytokines in the pathogenesis of restenosis after percutaneous transluminal coronary angioplasty
Autore:
Tashiro, H; Shimokawa, H; Sadamatsu, K; Aoki, T; Yamamoto, K;
Indirizzi:
St Marys Hosp, Div Cardiol, Kurume, Fukuoka, Japan St Marys Hosp Kurume Fukuoka Japan , Div Cardiol, Kurume, Fukuoka, Japan Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka, Japan Kyushu Univ Fukuoka Japan Med Sci, Dept Cardiovasc Med, Fukuoka, Japan
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 2, volume: 12, anno: 2001,
pagine: 107 - 113
SICI:
0954-6928(200103)12:2<107:ROCITP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; SMOOTH-MUSCLE CELLS; UNSTABLE ANGINA; POSTANGIOPLASTY RESTENOSIS; STENT IMPLANTATION; PROGNOSTIC VALUE; DISEASE; ATHEROSCLEROSIS; ARTERY; INTERLEUKIN-1;
Keywords:
cytokines; restenosis; coronary angioplasty; macrophage colony stimulating factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Shimokawa, H St Marys Hosp, Div Cardiol, Kurume, Fukuoka, Japan St Marys Hosp Kurume Fukuoka Japan , Kurume, Fukuoka, Japan
Citazione:
H. Tashiro et al., "Role of cytokines in the pathogenesis of restenosis after percutaneous transluminal coronary angioplasty", CORON ART D, 12(2), 2001, pp. 107-113

Abstract

Background Inflammatory cytokines play an important role in mediating inflammatory/proliferative responses including atherosclerosis, However, their role in the pathogenesis of restenosis after percutaneous transluminal coronary angioplasty (PTCA) remains to be clarified. Objective To determine plasma levels of inflammatory cytokines as well as cytokine-generation capacities of monocytes before PTCA and after the follow-up period. Methods Plasma levels of cytokines in 34 consecutive patients before and 3-6 months after PTCA were measured by enzyme-linked immunosorbent assay. Wemeasured the plasma levels of macrophage-colony-stimulating factor (MCSF) and transforming growth factor-beta, Cytokine-generation capacities of monocytes were also measured by a whole-blood induction method with lipopolysaccharide, The levels of cytokines measured for assessment of the capacities included those of interleukin-1 alpha, interleukin-1 beta, interleukin-6, granulocyte-colony-stimulating factor, tumor necrosis factor-alpha and interferon-gamma. Results Plasma levels of MCSF in patients without restenosis (n = 20) decreased significantly (from 1460 +/- 138 mug/ml before PTCA to 1039 +/- 125 mug/ml after the follow-up period, P < 0.01), whereas those in patients withrestenosis (n = 14) increased significantly (from 1107 +/- 105 <mu>g/ml before PTCA to 1039 +/- 125 mug/ml after the follow-up period, P < 0.05). We noted a positive correlation between the increase in plasma levels of MCSF and the extent of loss of lumen by restenosis, Cytokine-generation capacities of monocytes for interleukin-1<alpha> and interleukin-1 beta of patientswith restenosis significantly increased but those of patients without restenosis did not. Furthermore, plasma levels of C-reactive protein decreased significantly only in patients without restenosis after the follow-up period,Conclusions These results suggest that inflammatory changes mediated by cytokines may be involved in the pathogenesis of restenosis after PTCA, CoronArtery Dis 12:107-113 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:15:41